| GO:0043565 |
6 |
sequence-specific DNA binding |
F |
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
| GO:0003700 |
3 |
transcription factor activity, sequence-specific DNA binding |
F |
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. |
| GO:0005634 |
5 |
nucleus |
C |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| GO:0006355 |
6 |
regulation of transcription, DNA-templated |
P |
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| GO:0001077 |
6 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding |
F |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
| GO:0003677 |
5 |
DNA binding |
F |
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| GO:0000978 |
10 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding |
F |
Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II. |