The 11 common GO terms of the PCTFP (Ume6-Ash1)

GO ID GO Level GO Term GO Aspect GO Term Definition
GO:0043565 6 sequence-specific DNA binding F Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
GO:0033698 6 Rpd3L complex C A histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, an Sds-3 family protein, a SIN3 family co-repressor, a WD repeat protein, and a zf- PHD finger (Clr6, Sds3, Pst1, Prw1, Png2 in Schizosaccharomyces pombe; Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p and Ash1p in Saccharomyces cerevisiae).
GO:0005634 5 nucleus C A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
GO:0070210 5 Rpd3L-Expanded complex C A protein complex that contains a histone deacetylase and is part of the chromatin remodeling machinery. In Saccharomyces cerevisiae this complex contains the Rpd3p, Sin3p, Ume1p, Pho23p, Sap30p, Sds3p, Cti6p, Rxt2p, Rxt3p, Dep1p, Ume6p, Ash1p, Dot6p, Snt1, Sif2p, Set3p, Hos2p, Tos4p and Tod6p proteins.
GO:0006355 6 regulation of transcription, DNA-templated P Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0008270 7 zinc ion binding F Interacting selectively and non-covalently with zinc (Zn) ions.
GO:0003677 5 DNA binding F Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0046872 5 metal ion binding F Interacting selectively and non-covalently with any metal ion.
GO:0001078 6 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding F Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.
GO:0016568 6 chromatin modification P The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure.
GO:0006351 6 transcription, DNA-templated P The cellular synthesis of RNA on a template of DNA.