GO:0043565 |
6 |
sequence-specific DNA binding |
F |
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
GO:0071930 |
7 |
negative regulation of transcription involved in G1/S transition of mitotic cell cycle |
P |
Any process that stop, prevents or decreases transcription as part of the G1/S transition of the mitotic cell cycle. |
GO:0005634 |
5 |
nucleus |
C |
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
GO:0001191 |
5 |
transcriptional repressor activity, RNA polymerase II transcription factor binding |
F |
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well. |
GO:0006355 |
6 |
regulation of transcription, DNA-templated |
P |
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
GO:0000790 |
4 |
nuclear chromatin |
C |
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus. |
GO:0000977 |
9 |
RNA polymerase II regulatory region sequence-specific DNA binding |
F |
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. |
GO:0003677 |
5 |
DNA binding |
F |
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
GO:0007049 |
4 |
cell cycle |
P |
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
GO:0006351 |
6 |
transcription, DNA-templated |
P |
The cellular synthesis of RNA on a template of DNA. |