The 63 papers which experimentally study the biological roles of both TFs of the PCTFP (Aft1-Aft2)
Liang Y, et al. (2010) Role of Candida albicans Aft2p transcription factor in ferric reductase activity, morphogenesis and virulence. Microbiology 156(Pt 10):2912-2919
E Portnoy M, et al. (2002) The distinct methods by which manganese and iron regulate the Nramp transporters in yeast. Biochem J 362(Pt 1):119-24
Philpott CC and Protchenko O (2008) Response to Iron Deprivation in Saccharomyces cerevisiae. Eukaryot Cell 7(1):20-7
Wofford JD and Lindahl PA (2015) Mitochondrial Iron-Sulfur Cluster Activity and Cytosolic Iron Regulate Iron Traffic in Saccharomyces cerevisiae. J Biol Chem 290(45):26968-77
Qi J, et al. (2012) Metal-sensing transcription factors Mac1p and Aft1p coordinately regulate vacuolar copper transporter CTR2 in Saccharomyces cerevisiae. Biochem Biophys Res Commun 423(2):424-8
Zheng J, et al. (2010) Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol 6():420
Blaiseau PL, et al. (2001) Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem 276(36):34221-6
Rutherford JC and Bird AJ (2004) Metal-responsive transcription factors that regulate iron, zinc, and copper homeostasis in eukaryotic cells. Eukaryot Cell 3(1):1-13
van Bakel H, et al. (2005) Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism. Physiol Genomics 22(3):356-67
Dlouhy AC and Outten CE (2013) The iron metallome in eukaryotic organisms. Met Ions Life Sci 12():241-78
Ayer A, et al. (2010) The critical role of glutathione in maintenance of the mitochondrial genome. Free Radic Biol Med 49(12):1956-68
Lu CC, et al. (2008) Extracting transcription factor binding sites from unaligned gene sequences with statistical models. BMC Bioinformatics 9 Suppl 12:S7
Conde E Silva N, et al. (2009) KlAft, the Kluyveromyces lactis ortholog of Aft1 and Aft2, mediates activation of iron-responsive transcription through the PuCACCC Aft-type sequence. Genetics 183(1):93-106
Masse E and Arguin M (2005) Ironing out the problem: new mechanisms of iron homeostasis. Trends Biochem Sci 30(8):462-8
Veatch JR, et al. (2009) Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell 137(7):1247-58
Schroder I, et al. (2003) Microbial ferric iron reductases. FEMS Microbiol Rev 27(2-3):427-47
Rutherford JC, et al. (2003) Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem 278(30):27636-43
Franken J and Bauer FF (2010) Carnitine supplementation has protective and detrimental effects in Saccharomyces cerevisiae that are genetically mediated. FEMS Yeast Res 10(3):270-81
Rutherford JC, et al. (2001) A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A 98(25):14322-7
Dubacq C, et al. (2006) Role of the iron mobilization and oxidative stress regulons in the genomic response of yeast to hydroxyurea. Mol Genet Genomics 275(2):114-24
Ueta R, et al. (2007) Mechanism Underlying the Iron-dependent Nuclear Export of the Iron-responsive Transcription Factor Aft1p in Saccharomyces cerevisiae. Mol Biol Cell 18(8):2980-90
Berthelet S, et al. (2010) Functional Genomics Analysis of the Saccharomyces cerevisiae Iron Responsive Transcription Factor Aft1 Reveals Iron-Independent Functions. Genetics 185(3):1111-28
Dhaoui M, et al. (2011) Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis. Mol Biol Cell 22(12):2054-67
Miller C, et al. (2011) Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast. Mol Syst Biol 7():458
Andrew AJ, et al. (2008) Posttranslational regulation of the scaffold for Fe-S cluster biogenesis, Isu. Mol Biol Cell 19(12):5259-66
Batista-Nascimento L, et al. (2013) Yeast protective response to arsenate involves the repression of the high affinity iron uptake system. Biochim Biophys Acta 1833(5):997-1005
Murray DB, et al. (2011) Redox regulation in respiring Saccharomyces cerevisiae. Biochim Biophys Acta 1810(10):945-58
Lai WK and Buck MJ (2013) An integrative approach to understanding the combinatorial histone code at functional elements. Bioinformatics 29(18):2231-7
Rutherford JC, et al. (2005) Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis. J Biol Chem 280(11):10135-40
Ozer HK, et al. (2015) Cytosolic Fe-S Cluster Protein Maturation and Iron Regulation Are Independent of the Mitochondrial Erv1/Mia40 Import System. J Biol Chem 290(46):27829-40
Martinez-Pastor MT, et al. (2013) Post-Transcriptional Regulation of Iron Homeostasis in Saccharomyces cerevisiae. Int J Mol Sci 14(8):15785-809
Li H and Outten CE (2012) Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis. Biochemistry 51(22):4377-89
Outten CE and Albetel AN (2013) Iron sensing and regulation in Saccharomyces cerevisiae: Ironing out the mechanistic details. Curr Opin Microbiol 16(6):662-8
Zhao Y, et al. (2008) Development of a Novel Oligonucleotide Array-Based Transcription Factor Assay Platform for Genome-Wide Active Transcription Factor Profiling in Saccharomyces cerevisiae. J Proteome Res 7(3):1315-1325
Vergara SV and Thiele DJ (2008) Post-transcriptional regulation of gene expression in response to iron deficiency: co-ordinated metabolic reprogramming by yeast mRNA-binding proteins. Biochem Soc Trans 36(Pt 5):1088-90
Zhang Y, et al. (2014) Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis. Proc Natl Acad Sci U S A 111(17):E1695-704
Jothi R, et al. (2009) Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture. Mol Syst Biol 5:294
Cyert MS and Philpott CC (2013) Regulation of cation balance in Saccharomyces cerevisiae. Genetics 193(3):677-713
Gordan R, et al. (2011) Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol 12(12):R125
Goncalves IR, et al. (2014) The Basis for Evolution of DNA-Binding Specificity of the Aft1 Transcription Factor in Yeasts. Genetics 196(1):149-60
Kaplan J, et al. (2006) Iron-dependent metabolic remodeling in S. cerevisiae. Biochim Biophys Acta 1763(7):646-51
An X, et al. (2015) The late-annotated small ORF LSO1 is a target gene of the iron regulon of Saccharomyces cerevisiae. Microbiologyopen 4(6):941-51
Salvail H and Masse E (2011) Regulating iron storage and metabolism with RNA: an overview of posttranscriptional controls of intracellular iron homeostasis. Wiley Interdiscip Rev RNA 3(1):26-36
Slavov N, et al. (2014) Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. Cell Rep 7(3):705-14
Castells-Roca L, et al. (2011) The oxidative stress response in yeast cells involves changes in the stability of Aft1 regulon mRNAs. Mol Microbiol 81(1):232-48
Kumar C, et al. (2011) Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control. EMBO J 30(10):2044-56
Foster AW, et al. (2014) A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae. Mol Microbiol 93(2):317-30
Poor CB, et al. (2014) Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2. Proc Natl Acad Sci U S A 111(11):4043-8
Ehrensberger KM and Bird AJ (2011) Hammering out details: regulating metal levels in eukaryotes. Trends Biochem Sci 36(10):524-31
Courel M, et al. (2005) Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol 25(15):6760-71
Achcar F, et al. (2011) A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress. BMC Syst Biol 5(1):51
Zhang C (2014) Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control. Protein Cell 5(10):750-60
Philpott CC, et al. (2012) Metabolic remodeling in iron-deficient fungi. Biochim Biophys Acta 1823(9):1509-20
Babbitt GA (2010) Relaxed selection against accidental binding of transcription factors with conserved chromatin contexts. Gene 466(1-2):43-8
Rosenfeld L, et al. (2010) The effect of phosphate accumulation on metal ion homeostasis in Saccharomyces cerevisiae. J Biol Inorg Chem 15(7):1051-62
O'Doherty PJ, et al. (2013) Transcriptomic insights into the molecular response of Saccharomyces cerevisiae to linoleic acid hydroperoxide. Free Radic Res 47(12):1054-65
Puig S, et al. (2005) Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation. Cell 120(1):99-110
Babu MM, et al. (2006) The natural history of the WRKY-GCM1 zinc fingers and the relationship between transcription factors and transposons. Nucleic Acids Res 34(22):6505-20
Kaplan CD and Kaplan J (2005) Regulatory oversight of the iron trade: posttranscriptional regulation in yeast. Cell Metab 2(1):4-6
Puig S, et al. (2008) Cooperation of two mRNA-binding proteins drives metabolic adaptation to iron deficiency. Cell Metab 7(6):555-64
Fordyce PM, et al. (2010) De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis. Nat Biotechnol 28(9):970-5
De Freitas JM, et al. (2004) Exploratory and confirmatory gene expression profiling of mac1Delta. J Biol Chem 279(6):4450-8
Morris RT, et al. (2010) Ceres: software for the integrated analysis of transcription factor binding sites and nucleosome positions in Saccharomyces cerevisiae. Bioinformatics 26(2):168-74