The 121 papers which experimentally study the biological roles of both TFs of the PCTFP (Gln3-Gat1)
Chen H and Fink GR (2006) Feedback control of morphogenesis in fungi by aromatic alcohols. Genes Dev 20(9):1150-61
Vinterova Z, et al. (2013) Saccharomyces cerevisiae can secrete Sapp1p proteinase of Candida parapsilosis but cannot use it for efficient nitrogen acquisition. J Microbiol 51(3):336-44
Zheng J, et al. (2010) Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol 6():420
Neklesa TK and Davis RW (2009) A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex. PLoS Genet 5(6):e1000515
Feller A, et al. (2013) Alterations in the Ure2 aCap domain elicit different GATA factor responses to rapamycin treatment and nitrogen limitation. J Biol Chem 288(3):1841-55
Cooper T (2002) Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots. FEMS Microbiol Rev 26(3):223-38
van Der Merwe GK, et al. (2001) Ammonia regulates VID30 expression and Vid30p function shifts nitrogen metabolism toward glutamate formation especially when Saccharomyces cerevisiae is grown in low concentrations of ammonia. J Biol Chem 276(31):28659-66
Arino J, et al. (2010) Alkali metal cation transport and homeostasis in yeasts. Microbiol Mol Biol Rev 74(1):95-120
Kulkarni A, et al. (2006) Differing responses of Gat1 and Gln3 phosphorylation and localization to rapamycin and methionine sulfoximine treatment in Saccharomyces cerevisiae. FEMS Yeast Res 6(2):218-29
Leverentz MK, et al. (2009) Mutation of a Phosphorylatable Residue in Put3p Affects the Magnitude of Rapamycin-induced PUT1 Activation in a Gat1p-dependent Manner. J Biol Chem 284(36):24115-22
Stanbrough M, et al. (1995) Role of the GATA factors Gln3p and Nil1p of Saccharomyces cerevisiae in the expression of nitrogen-regulated genes. Proc Natl Acad Sci U S A 92(21):9450-4
Beskow A and Wright AP (2006) Comparative analysis of regulatory transcription factors in Schizosaccharomyces pombe and budding yeasts. Yeast 23(13):929-35
Zhao Y, et al. (2008) Development of a Novel Oligonucleotide Array-Based Transcription Factor Assay Platform for Genome-Wide Active Transcription Factor Profiling in Saccharomyces cerevisiae. J Proteome Res 7(3):1315-1325
Springael JY and Penninckx MJ (2003) Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3. Biochem J 371(Pt 2):589-95
Barnett JA (2008) A history of research on yeasts 13. Active transport and the uptake of various metabolites. Yeast 25(10):689-731
Wu WS and Chen BS (2009) Identifying Stress Transcription Factors Using Gene Expression and TF-Gene Association Data. Bioinform Biol Insights 1():137-45
Lai FJ, et al. (2014) A comprehensive performance evaluation on the prediction results of existing cooperative transcription factors identification algorithms. BMC Syst Biol 8 Suppl 4():S9
Barea F and Bonatto D (2009) Aging defined by a chronologic-replicative protein network in Saccharomyces cerevisiae: an interactome analysis. Mech Ageing Dev 130(7):444-60
Coffman JA and Cooper TG (1997) Nitrogen GATA factors participate in transcriptional regulation of vacuolar protease genes in Saccharomyces cerevisiae. J Bacteriol 179(17):5609-13
Georis I, et al. (2008) Tor Pathway Control of the Nitrogen-responsive DAL5 Gene Bifurcates at the Level of Gln3 and Gat1 Regulation in Saccharomyces cerevisiae. J Biol Chem 283(14):8919-29
Jin M and Klionsky DJ (2014) Regulation of autophagy: Modulation of the size and number of autophagosomes. FEBS Lett 588(15):2457-2463
Babbitt GA (2010) Relaxed selection against accidental binding of transcription factors with conserved chromatin contexts. Gene 466(1-2):43-8
Tate JJ, et al. (2002) Mks1p is required for negative regulation of retrograde gene expression in Saccharomyces cerevisiae but does not affect nitrogen catabolite repression-sensitive gene expression. J Biol Chem 277(23):20477-82
Rai R, et al. (2015) Nuclear Gln3 Import Is Regulated by Nitrogen Catabolite Repression Whereas Export Is Specifically Regulated by Glutamine. Genetics 201(3):989-1016
Rai R, et al. (1999) Overlapping positive and negative GATA factor binding sites mediate inducible DAL7 gene expression in Saccharomyces cerevisiae. J Biol Chem 274(39):28026-34
Madeira JB, et al. (2015) TORC1 Inhibition Induces Lipid Droplet Replenishment in Yeast. Mol Cell Biol 35(4):737-46
Cunningham TS, et al. (2000) Nitrogen catabolite repression of DAL80 expression depends on the relative levels of Gat1p and Ure2p production in Saccharomyces cerevisiae. J Biol Chem 275(19):14408-14
Gstaiger M, et al. (2003) Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science 302(5648):1208-12
Coffman JA, et al. (1997) Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae. J Bacteriol 179(11):3416-29
Georis I, et al. (2009) The yeast GATA factor Gat1 occupies a central position in nitrogen catabolite repression-sensitive gene activation. Mol Cell Biol 29(13):3803-15
Pires EJ, et al. (2014) Yeast: the soul of beer's aroma-a review of flavour-active esters and higher alcohols produced by the brewing yeast. Appl Microbiol Biotechnol 98(5):1937-49
Aris JP, et al. (2012) Amino Acid Homeostasis and Chronological Longevity in Saccharomyces cerevisiae. Subcell Biochem 57():161-86
Svetlov VV and Cooper TG (1998) The Saccharomyces cerevisiae GATA factors Dal80p and Deh1p can form homo- and heterodimeric complexes. J Bacteriol 180(21):5682-8
Schmelzle T, et al. (2004) Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast. Mol Cell Biol 24(1):338-51
Yu T and Li KC (2005) Inference of transcriptional regulatory network by two-stage constrained space factor analysis. Bioinformatics 21(21):4033-8
Tuite MF (2015) Yeast prions: Paramutation at the protein level? Semin Cell Dev Biol 44():51-61
Stanbrough M and Magasanik B (1996) Two transcription factors, Gln3p and Nil1p, use the same GATAAG sites to activate the expression of GAP1 of Saccharomyces cerevisiae. J Bacteriol 178(8):2465-8
Rodkaer SV and Faergeman NJ (2014) Glucose- and nitrogen sensing and regulatory mechanisms in Saccharomyces cerevisiae. FEMS Yeast Res 14(5):683-96
Michoel T, et al. (2009) Comparative analysis of module-based versus direct methods for reverse-engineering transcriptional regulatory networks. BMC Syst Biol 3:49
Makanae K, et al. (2013) Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method. Genome Res 23(2):300-11
Giannattasio S, et al. (2005) Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression. J Biol Chem 280(52):42528-35
Oliveira EM, et al. (2005) Gln3p and Nil1p regulation of invertase activity and SUC2 expression in Saccharomyces cerevisiae. FEMS Yeast Res 5(6-7):605-9
Kakiuchi K, et al. (2007) Proteomic analysis of in vivo 14-3-3 interactions in the yeast Saccharomyces cerevisiae. Biochemistry 46(26):7781-92
Crespo JL, et al. (2004) NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae. J Biol Chem 279(36):37512-7
Rodriguez C, et al. (2013) Nitrogen-dependent calcineurin activation in the yeast Hansenula polymorpha. Fungal Genet Biol 53():34-41
Bandhakavi S, et al. (2008) Hsf1 Activation Inhibits Rapamycin Resistance and TOR Signaling in Yeast Revealed by Combined Proteomic and Genetic Analysis. PLoS One 3(2):e1598
Teixeira V and Costa V (2016) Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism. Prog Lipid Res 61():109-33
Wong KH, et al. (2008) Recent advances in nitrogen regulation: a comparison between Saccharomyces cerevisiae and filamentous fungi. Eukaryot Cell 7(6):917-25
Fayyadkazan M, et al. (2014) Components of Golgi-to-vacuole trafficking are required for nitrogen- and TORC1-responsive regulation of the yeast GATA factors. Microbiologyopen 3(3):271-87
Georis I, et al. (2009) Nitrogen Catabolite Repression-Sensitive Transcription as a Readout of Tor Pathway Regulation: The Genetic Background, Reporter Gene and GATA Factor Assayed Determine the Outcomes. Genetics 181(3):861-74
Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31
Lu CC, et al. (2008) Extracting transcription factor binding sites from unaligned gene sequences with statistical models. BMC Bioinformatics 9 Suppl 12:S7
Ljungdahl PO and Daignan-Fornier B (2012) Regulation of Amino Acid, Nucleotide, and Phosphate Metabolism in Saccharomyces cerevisiae. Genetics 190(3):885-929
Fayyad-Kazan M, et al. (2016) Yeast nitrogen catabolite repression is sustained by signals distinct from glutamine and glutamate reservoirs. Mol Microbiol 99(2):360-79
Magasanik B and Kaiser CA (2002) Nitrogen regulation in Saccharomyces cerevisiae. Gene 290(1-2):1-18
van Werven FJ and Amon A (2011) Regulation of entry into gametogenesis. Philos Trans R Soc Lond B Biol Sci 366(1584):3521-31
Stanbrough M and Magasanik B (1995) Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae. J Bacteriol 177(1):94-102
Conrad M, et al. (2014) Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 38(2):254-99
Huber A, et al. (2009) Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev 23(16):1929-43
Tate JJ and Cooper TG (2008) Formalin can alter the intracellular localization of some transcription factors in Saccharomyces cerevisiae. FEMS Yeast Res 8(8):1223-35
Huang YC, et al. (2010) Intragenic transcription of a noncoding RNA modulates expression of ASP3 in budding yeast. RNA 16(11):2085-93
Coffman JA, et al. (1995) Genetic evidence for Gln3p-independent, nitrogen catabolite repression-sensitive gene expression in Saccharomyces cerevisiae. J Bacteriol 177(23):6910-8
Lee K and Hahn JS (2013) Interplay of Aro80 and GATA activators in regulation of genes for catabolism of aromatic amino acids in Saccharomyces cerevisiae. Mol Microbiol 88(6):1120-34
Goranov AI, et al. (2013) Changes in Cell Morphology Are Coordinated with Cell Growth through the TORC1 Pathway. Curr Biol 23(14):1269-79
Erb I and van Nimwegen E (2011) Transcription factor binding site positioning in yeast: proximal promoter motifs characterize tata-less promoters. PLoS One 6(9):e24279
Park HD, et al. (1999) Synergistic operation of the CAR2 (Ornithine transaminase) promoter elements in Saccharomyces cerevisiae. J Bacteriol 181(22):7052-64
Georis I, et al. (2011) Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine. J Biol Chem 286(52):44897-912
Marini AM, et al. (1997) A family of ammonium transporters in Saccharomyces cerevisiae. Mol Cell Biol 17(8):4282-93
Kuruvilla FG, et al. (2001) Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors. Proc Natl Acad Sci U S A 98(13):7283-8
Gordan R, et al. (2011) Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol 12(12):R125
Urban J, et al. (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 26(5):663-74
Crespo JL, et al. (2002) The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci U S A 99(10):6784-9
Staschke KA, et al. (2010) Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. J Biol Chem 285(22):16893-911
Valenzuela L, et al. (1998) Regulation of expression of GLT1, the gene encoding glutamate synthase in Saccharomyces cerevisiae. J Bacteriol 180(14):3533-40
Kulkarni AA, et al. (2001) Gln3p nuclear localization and interaction with Ure2p in Saccharomyces cerevisiae. J Biol Chem 276(34):32136-44
van der Merwe GK, et al. (2001) Cis-acting sites contributing to expression of divergently transcribed DAL1 and DAL4 genes in S. cerevisiae: a word of caution when correlating cis-acting sequences with genome-wide expression analyses. Curr Genet 39(3):156
Luzzani C, et al. (2007) New insights into the regulation of the Saccharomyces cerevisiae UGA4 gene: two parallel pathways participate in carbon-regulated transcription. Microbiology 153(Pt 11):3677-3684
Iraqui I, et al. (1999) Transcriptional induction by aromatic amino acids in Saccharomyces cerevisiae. Mol Cell Biol 19(5):3360-71
Homann OR, et al. (2009) A phenotypic profile of the Candida albicans regulatory network. PLoS Genet 5(12):e1000783
Soussi-Boudekou S and Andre B (1999) A co-activator of nitrogen-regulated transcription in Saccharomyces cerevisiae. Mol Microbiol 31(3):753-62
Tate JJ, et al. (2010) Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and rapamycin treatment in Saccharomyces cerevisiae. J Biol Chem 285(23):17880-95
Lai WK and Buck MJ (2013) An integrative approach to understanding the combinatorial histone code at functional elements. Bioinformatics 29(18):2231-7
Swiecilo A (2016) Cross-stress resistance in Saccharomyces cerevisiae yeast-new insight into an old phenomenon. Cell Stress Chaperones ()
Bernard A, et al. (2015) A large-scale analysis of autophagy-related gene expression identifies new regulators of autophagy. Autophagy 11(11):2114-2122
Geertz M, et al. (2012) Massively parallel measurements of molecular interaction kinetics on a microfluidic platform. Proc Natl Acad Sci U S A 109(41):16540-5
Laor D, et al. (2015) TORC1 Regulates Developmental Responses to Nitrogen Stress via Regulation of the GATA Transcription Factor Gaf1. MBio 6(4)
Zhao X, et al. (2013) Nitrogen regulation involved in the accumulation of urea in Saccharomyces cerevisiae. Yeast 30(11):437-47
Garcia-Salcedo R, et al. (2006) Heterologous Expression Implicates a GATA Factor in Regulation of Nitrogen Metabolic Genes and Ion Homeostasis in the Halotolerant Yeast Debaryomyces hansenii. Eukaryot Cell 5(8):1388-98
Coffman JA, et al. (1996) Gat1p, a GATA family protein whose production is sensitive to nitrogen catabolite repression, participates in transcriptional activation of nitrogen-catabolic genes in Saccharomyces cerevisiae. Mol Cell Biol 16(3):847-58
Rubio-Texeira M (2007) Urmylation controls Nil1p and Gln3p-dependent expression of nitrogen-catabolite repressed genes in Saccharomyces cerevisiae. FEBS Lett 581(3):541-50
Morozov AV and Siggia ED (2007) Connecting protein structure with predictions of regulatory sites. Proc Natl Acad Sci U S A 104(17):7068-73
Mas S, et al. (2007) A comparison of direct infusion MS and GC-MS for metabolic footprinting of yeast mutants. Biotechnol Bioeng 96(5):1014-22
Georis I, et al. (2011) Intranuclear Function for Protein Phosphatase 2A: Pph21 and Pph22 Are Required for Rapamycin-Induced GATA Factor Binding to the DAL5 Promoter in Yeast. Mol Cell Biol 31(1):92-104
Saxena D, et al. (2003) Rapamycin treatment results in GATA factor-independent hyperphosphorylation of the proline utilization pathway activator in Saccharomyces cerevisiae. Eukaryot Cell 2(3):552-9
Gonzalez A, et al. (2009) Normal function of the yeast TOR pathway requires the type 2C protein phosphatase Ptc1. Mol Cell Biol 29(10):2876-88
Tate JJ, et al. (2015) Nitrogen Starvation and TorC1 Inhibition Differentially Affect Nuclear Localization of the Gln3 and Gat1 Transcription Factors Through the Rare Glutamine tRNACUG in Saccharomyces cerevisiae. Genetics 199(2):455-74
Oliveira EM, et al. (2003) The role of the GATA factors Gln3p, Nil1p, Dal80p and the Ure2p on ASP3 regulation in Saccharomyces cerevisiae. Yeast 20(1):31-7
Bertram PG, et al. (2000) Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases. J Biol Chem 275(46):35727-33
Hofman-Bang J (1999) Nitrogen catabolite repression in Saccharomyces cerevisiae. Mol Biotechnol 12(1):35-73
Crespo JL, et al. (2001) The GATA transcription factors GLN3 and GAT1 link TOR to salt stress in Saccharomyces cerevisiae. J Biol Chem 276(37):34441-4
Shamji AF, et al. (2000) Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins. Curr Biol 10(24):1574-81
Sosa E, et al. (2003) Gcn4 negatively regulates expression of genes subjected to nitrogen catabolite repression. Biochem Biophys Res Commun 310(4):1175-80
Shewmaker F, et al. (2007) Ure2p Function Is Enhanced by Its Prion Domain in Saccharomyces cerevisiae. Genetics 176(3):1557-65
Distler M, et al. (2001) Green fluorescent protein-Dal80p illuminates up to 16 distinct foci that colocalize with and exhibit the same behavior as chromosomal DNA proceeding through the cell cycle of Saccharomyces cerevisiae. J Bacteriol 183(15):4636-42
Gerstein AC, et al. (2015) Too much of a good thing: the unique and repeated paths toward copper adaptation. Genetics 199(2):555-71
Svetlov V and Cooper TG (1997) The minimal transactivation region of Saccharomyces cerevisiae Gln3p is localized to 13 amino acids. J Bacteriol 179(24):7644-52
Gagiano M, et al. (2002) The sensing of nutritional status and the relationship to filamentous growth in Saccharomyces cerevisiae. FEMS Yeast Res 2(4):433-70
Harari Y, et al. (2013) Nature vs nurture: Interplay between the genetic control of telomere length and environmental factors. Cell Cycle 12(22):3465-70
Cunningham TS, et al. (2000) The level of DAL80 expression down-regulates GATA factor-mediated transcription in Saccharomyces cerevisiae. J Bacteriol 182(23):6584-91
Scott S, et al. (2000) Roles of the Dal82p domains in allophanate/oxalurate-dependent gene expression in Saccharomyces cerevisiae. J Biol Chem 275(40):30886-93
Alberghina L, et al. (2011) Cell growth and cell cycle in Saccharomyces cerevisiae: basic regulatory design and protein-protein interaction network. Biotechnol Adv 30(1):52-72
Rowen DW, et al. (1997) Role of GATA factor Nil2p in nitrogen regulation of gene expression in Saccharomyces cerevisiae. J Bacteriol 179(11):3761-6
Soussi-Boudekou S, et al. (1997) Gzf3p, a fourth GATA factor involved in nitrogen-regulated transcription in Saccharomyces cerevisiae. Mol Microbiol 23(6):1157-68
Isabelle G, et al. (2015) Premature termination of GAT1 transcription explains paradoxical negative correlation between nitrogen-responsive mRNA, but constitutive low-level protein production. RNA Biol 12(8):824-37
Kuruvilla FG, et al. (2002) Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays. Nature 416(6881):653-7
Cox KH, et al. (2000) Saccharomyces cerevisiae GATA sequences function as TATA elements during nitrogen catabolite repression and when Gln3p is excluded from the nucleus by overproduction of Ure2p. J Biol Chem 275(23):17611-8
Arino J (2010) Integrative Responses to High pH Stress in S. cerevisiae. OMICS 14(5):517-23
ter Schure EG, et al. (2000) The role of ammonia metabolism in nitrogen catabolite repression in Saccharomyces cerevisiae. FEMS Microbiol Rev 24(1):67-83
Ungar L, et al. (2011) Tor complex 1 controls telomere length by affecting the level of Ku. Curr Biol 21(24):2115-20
Zhao S, et al. (2014) Comparative proteomic analysis of Saccharomyces cerevisiae under different nitrogen sources. J Proteomics 101():102-12
Scherens B, et al. (2006) Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term. FEMS Yeast Res 6(5):777-91