The 46 papers which experimentally study the biological roles of both TFs of the PCTFP (Hap4-Hap1)
Smith JJ, et al. (2011) Environment-responsive transcription factors bind subtelomeric elements and regulate gene silencing. Mol Syst Biol 7():455
Schneider JC and Guarente L (1991) Regulation of the yeast CYT1 gene encoding cytochrome c1 by HAP1 and HAP2/3/4. Mol Cell Biol 11(10):4934-42
Costa V and Moradas-Ferreira P (2001) Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases. Mol Aspects Med 22(4-5):217-46
Kwast KE, et al. (1998) Oxygen sensing and the transcriptional regulation of oxygen-responsive genes in yeast. J Exp Biol 201(Pt 8):1177-95
Wong CM, et al. (2003) Transcriptional regulation of yeast peroxiredoxin gene TSA2 through Hap1p, Rox1p, and Hap2/3/5p. Free Radic Biol Med 34(5):585-97
Scandalios JG (2005) Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses. Braz J Med Biol Res 38(7):995-1014
Zheng J, et al. (2010) Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol 6():420
Rao AR and Pellegrini M (2011) Regulation of the yeast metabolic cycle by transcription factors with periodic activities. BMC Syst Biol 5(1):160
Murray DB, et al. (2011) Redox regulation in respiring Saccharomyces cerevisiae. Biochim Biophys Acta 1810(10):945-58
Bunn HF and Poyton RO (1996) Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76(3):839-85
Wu WS, et al. (2006) Computational reconstruction of transcriptional regulatory modules of the yeast cell cycle. BMC Bioinformatics 7(1):421
Rosenfeld E and Beauvoit B (2003) Role of the non-respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae. Yeast 20(13):1115-44
Kundaje A, et al. (2008) A predictive model of the oxygen and heme regulatory network in yeast. PLoS Comput Biol 4(11):e1000224
Crawford MJ, et al. (1995) Regulation of Saccharomyces cerevisiae flavohemoglobin gene expression. J Biol Chem 270(12):6991-6
Zhang Y, et al. (2013) Using gene expression programming to infer gene regulatory networks from time-series data. Comput Biol Chem 47():198-206
Yu T and Li KC (2005) Inference of transcriptional regulatory network by two-stage constrained space factor analysis. Bioinformatics 21(21):4033-8
Kaniak-Golik A and Skoneczna A (2015) Mitochondria-nucleus network for genome stability. Free Radic Biol Med 82():73-104
Lee E and Bussemaker HJ (2010) Identifying the genetic determinants of transcription factor activity. Mol Syst Biol 6():412
Zhang L and Hach A (1999) Molecular mechanism of heme signaling in yeast: the transcriptional activator Hap1 serves as the key mediator. Cell Mol Life Sci 56(5-6):415-26
Bussereau F, et al. (2006) The Kluyveromyces lactis repertoire of transcriptional regulators. FEMS Yeast Res 6(3):325-35
Swamy KB, et al. (2009) Impact of DNA-binding position variants on yeast gene expression. Nucleic Acids Res 37(21):6991-7001
Ward LD and Bussemaker HJ (2008) Predicting functional transcription factor binding through alignment-free and affinity-based analysis of orthologous promoter sequences. Bioinformatics 24(13):i165-71
Wiebe MG, et al. (2008) Central carbon metabolism of Saccharomyces cerevisiae in anaerobic, oxygen-limited and fully aerobic steady-state conditions and following a shift to anaerobic conditions. FEMS Yeast Res 8(1):140-54
Kennedy MA, et al. (1999) Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1445(1):110-22
Lodi T, et al. (1999) Regulation of the Saccharomyces cerevisiae DLD1 gene encoding the mitochondrial protein D-lactate ferricytochrome c oxidoreductase by HAP1 and HAP2/3/4/5. Mol Gen Genet 262(4-5):623-32
Lai LC, et al. (2006) Metabolic-state-dependent remodeling of the transcriptome in response to anoxia and subsequent reoxygenation in Saccharomyces cerevisiae. Eukaryot Cell 5(9):1468-89
Ramil E, et al. (2000) Regulation of the CYB2 gene expression: transcriptional co-ordination by the Hap1p, Hap2/3/4/5p and Adr1p transcription factors. Mol Microbiol 37(5):1116-32
Forsburg SL and Guarente L (1989) Communication between mitochondria and the nucleus in regulation of cytochrome genes in the yeast Saccharomyces cerevisiae. Annu Rev Cell Biol 5():153-80
Gonzalez Siso MI and Cerdan ME (2012) Kluyveromyces lactis: A Suitable Yeast Model to Study Cellular Defense Mechanisms against Hypoxia-Induced Oxidative Stress. Oxid Med Cell Longev 2012():634674
Lai LC, et al. (2008) Comparison of the transcriptomic "stress response" evoked by antimycin A and oxygen deprivation in saccharomyces cerevisiae. BMC Genomics 9:627
Poyton RO (1999) Models for oxygen sensing in yeast: implications for oxygen-regulated gene expression in higher eucaryotes. Respir Physiol 115(2):119-33
Geijer C, et al. (2012) Time course gene expression profiling of yeast spore germination reveals a network of transcription factors orchestrating the global response. BMC Genomics 13(1):554
Watt R and Piper PW (1997) UBI4, the polyubiquitin gene of Saccharomyces cerevisiae, is a heat shock gene that is also subject to catabolite derepression control. Mol Gen Genet 253(4):439-47
Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31
Ihrig J, et al. (2010) Iron Regulation through the Back Door: Iron-Dependent Metabolite Levels Contribute to Transcriptional Adaptation to Iron Deprivation in Saccharomyces cerevisiae. Eukaryot Cell 9(3):460-71
Breitenbach M, et al. (2012) The role of mitochondria in the aging processes of yeast. Subcell Biochem 57():55-78
Litvin O, et al. (2009) Modularity and interactions in the genetics of gene expression. Proc Natl Acad Sci U S A 106(16):6441-6
Zeng T and Li J (2010) Maximization of negative correlations in time-course gene expression data for enhancing understanding of molecular pathways. Nucleic Acids Res 38(1):e1
Dori-Bachash M, et al. (2011) Coupled evolution of transcription and mRNA degradation. PLoS Biol 9(7):e1001106
Goh WS, et al. (2010) Blurring of high-resolution data shows that the effect of intrinsic nucleosome occupancy on transcription factor binding is mostly regional, not local. PLoS Comput Biol 6(1):e1000649
Philpott CC, et al. (2012) Metabolic remodeling in iron-deficient fungi. Biochim Biophys Acta 1823(9):1509-20
Pinkham JL, et al. (1997) Heme regulates SOD2 transcription by activation and repression in Saccharomyces cerevisiae. Curr Genet 31(4):281-91
Sun W, et al. (2007) Detection of eQTL modules mediated by activity levels of transcription factors. Bioinformatics 23(17):2290-7
Jeffries TW and Shi NQ (1999) Genetic engineering for improved xylose fermentation by yeasts. Adv Biochem Eng Biotechnol 65():117-61
Netzer NC and Breitenbach M (2010) Metabolic changes through hypoxia in humans and in yeast as a comparable cell model. Sleep Breath 14(3):221-5
Morohashi N, et al. (2008) In vivo and in vitro footprinting of nucleosomes and transcriptional activators using an infrared-fluorescence DNA sequencer. Biol Pharm Bull 31(2):187-92