The 91 papers which experimentally study the biological roles of both TFs of the PCTFP (Hmlalpha1-Matalpha1)
Rine J and Herskowitz I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116(1):9-22
Butler G, et al. (2004) Evolution of the MAT locus and its Ho endonuclease in yeast species. Proc Natl Acad Sci U S A 101(6):1632-7
Hofmann JF, et al. (1989) RAP-1 factor is necessary for DNA loop formation in vitro at the silent mating type locus HML. Cell 57(5):725-37
Mukai Y, et al. (1993) Function of the ste signal transduction pathway for mating pheromones sustains MAT alpha 1 transcription in Saccharomyces cerevisiae. Mol Cell Biol 13(4):2050-60
Whiteway M, et al. (1987) The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Mol Cell Biol 7(10):3713-22
Caponigro G, et al. (1993) A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons. Mol Cell Biol 13(9):5141-8
Astell CR, et al. (1981) The sequence of the DNAs coding for the mating-type loci of Saccharomyces cerevisiae. Cell 27(1 Pt 2):15-23
Singh J and Klar AJ (1992) Active genes in budding yeast display enhanced in vivo accessibility to foreign DNA methylases: a novel in vivo probe for chromatin structure of yeast. Genes Dev 6(2):186-96
Mahoney DJ, et al. (1991) Mutations in the HML E silencer of Saccharomyces cerevisiae yield metastable inheritance of transcriptional repression. Genes Dev 5(4):605-15
Kurtz S and Shore D (1991) RAP1 protein activates and silences transcription of mating-type genes in yeast. Genes Dev 5(4):616-28
Livi GP, et al. (1990) The sum1-1 mutation affects silent mating-type gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 10(1):409-12
Inokuchi K, et al. (1988) Sequence-directed bends of DNA helix axis at the upstream activation sites of alpha-cell-specific genes in yeast. Nucleic Acids Res 16(14B):6693-711
Tanaka K, et al. (1984) Mating type control in Saccharomyces cerevisiae: a frameshift mutation at the common DNA sequence, X, of the HML alpha locus. Mol Cell Biol 4(1):203-11
Siliciano PG and Tatchell K (1984) Transcription and regulatory signals at the mating type locus in yeast. Cell 37(3):969-78
Laurenson P and Rine J (1992) Silencers, silencing, and heritable transcriptional states. Microbiol Rev 56(4):543-60
Strathern JN, et al. (1980) Structure and organization of transposable mating type cassettes in Saccharomyces yeasts. Proc Natl Acad Sci U S A 77(5):2839-43
Mastrangelo MF, et al. (1992) Disruption of a silencer domain by a retrotransposon. Genetics 131(3):519-29
Kyrion G, et al. (1993) RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev 7(7A):1146-59
Klebl B, et al. (2001) A comprehensive analysis of gene expression profiles in a yeast N-glycosylation mutant. Biochem Biophys Res Commun 286(4):714-20
Hennigan AN and Jacobson A (1996) Functional mapping of the translation-dependent instability element of yeast MATalpha1 mRNA. Mol Cell Biol 16(7):3833-43
Park EC and Szostak JW (1992) ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. EMBO J 11(6):2087-93
Connolly B, et al. (1988) Physical monitoring of mating type switching in Saccharomyces cerevisiae. Mol Cell Biol 8(6):2342-9
Bender A and Sprague GF Jr (1987) MAT alpha 1 protein, a yeast transcription activator, binds synergistically with a second protein to a set of cell-type-specific genes. Cell 50(5):681-91
Klar AJ, et al. (1985) SUM1, an apparent positive regulator of the cryptic mating-type loci in Saccharomyces cerevisiae. Genetics 111(4):745-58
Weiss K and Simpson RT (1998) High-resolution structural analysis of chromatin at specific loci: Saccharomyces cerevisiae silent mating type locus HMLalpha. Mol Cell Biol 18(9):5392-403
Yuan YO, et al. (1993) Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins. Genes Dev 7(8):1584-97
Sprague GF Jr, et al. (1983) Cell interactions and regulation of cell type in the yeast Saccharomyces cerevisiae. Annu Rev Microbiol 37:623-60
Herskowitz I and Marsh L (1987) Conservation of a receptor/signal transduction system. Cell 50(7):995-6
Ray BL, et al. (1991) The TSM1 gene of Saccharomyces cerevisiae overlaps the MAT locus. Curr Genet 20(1-2):25-31
Astrom SU, et al. (2000) Kluyveromyces lactis Sir2p regulates cation sensitivity and maintains a specialized chromatin structure at the cryptic alpha-locus. Genetics 156(1):81-91
Klar AJ, et al. (1981) Regulation of transcription in expressed and unexpressed mating type cassettes of yeast. Nature 289(5795):239-44
Nakazawa N, et al. (1991) AAR2, a gene for splicing pre-mRNA of the MATa1 cistron in cell type control of Saccharomyces cerevisiae. Mol Cell Biol 11(11):5693-700
Sprague GF Jr, et al. (1981) Homology and non-homology at the yeast mating type locus. Nature 289(5795):250-2
Nasmyth KA, et al. (1981) A position effect in the control of transcription at yeast mating type loci. Nature 289(5795):244-50
Gao LZ and Innan H (2004) Very low gene duplication rate in the yeast genome. Science 306(5700):1367-70
Fabre E, et al. (2005) Comparative genomics in hemiascomycete yeasts: evolution of sex, silencing, and subtelomeres. Mol Biol Evol 22(4):856-73
Liu C, et al. (1994) Mutational analysis defines a C-terminal tail domain of RAP1 essential for Telomeric silencing in Saccharomyces cerevisiae. Genetics 138(4):1025-40
Ammerer G, et al. (1985) Control of yeast alpha-specific genes: evidence for two blocks to expression in MATa/MAT alpha diploids. Proc Natl Acad Sci U S A 82(17):5855-9
Johnson LM, et al. (1990) Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 87(16):6286-90
Sprague GF Jr, et al. (1981) Control of yeast cell type by the mating type locus. II. Genetic interactions between MAT alpha and unlinked alpha-specific STE genes. J Mol Biol 153(2):323-35
Jacquet M, et al. (1991) The MAT locus revisited within a 9.8 kb fragment of chromosome III containing BUD5 and two new open reading frames. Yeast 7(8):881-8
Tan S, et al. (1988) Interactions of purified transcription factors: binding of yeast MAT alpha 1 and PRTF to cell type-specific, upstream activating sequences. EMBO J 7(13):4255-64
Weinstock KG, et al. (1990) Multimeric arrays of the yeast retrotransposon Ty. Mol Cell Biol 10(6):2882-92
Carr EA, et al. (2004) Alpha1-induced DNA bending is required for transcriptional activation by the Mcm1-alpha1 complex. Nucleic Acids Res 32(8):2298-305
Xu Q, et al. (1993) The Saccharomyces cerevisiae Cdc68 transcription activator is antagonized by San1, a protein implicated in transcriptional silencing. Mol Cell Biol 13(12):7553-65
Herskowitz I (1989) A regulatory hierarchy for cell specialization in yeast. Nature 342(6251):749-57
Shore D and Nasmyth K (1987) Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 51(5):721-32
Strathern JN, et al. (1979) Isolation of a circular derivative of yeast chromosome III: implications for the mechanism of mating type interconversion. Cell 18(2):309-19
Longtine MS, et al. (1993) Telomere-mediated plasmid segregation in Saccharomyces cerevisiae involves gene products required for transcriptional repression at silencers and telomeres. Genetics 133(2):171-82
Brand AH, et al. (1985) Characterization of a "silencer" in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer. Cell 41(1):41-8
Button LL and Astell CR (1986) The Saccharomyces cerevisiae chromosome III left telomere has a type X, but not a type Y', ARS region. Mol Cell Biol 6(4):1352-6
Kyrion G, et al. (1992) C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol Cell Biol 12(11):5159-73
Buchman AR, et al. (1988) Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae. Mol Cell Biol 8(1):210-25
Buck MJ and Lieb JD (2006) A chromatin-mediated mechanism for specification of conditional transcription factor targets. Nat Genet 38(12):1446-51
Inokuchi K, et al. (1987) Identification of sequence elements that confer cell-type-specific control of MF alpha 1 expression in Saccharomyces cerevisiae. Mol Cell Biol 7(9):3185-93
Katju V, et al. (2009) Variation in gene duplicates with low synonymous divergence in Saccharomyces cerevisiae relative to Caenorhabditis elegans. Genome Biol 10(7):R75
Klar AJ (2010) The yeast mating-type switching mechanism: a memoir. Genetics 186(2):443-9
Jothi R, et al. (2009) Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture. Mol Syst Biol 5:294
Siliciano PG and Tatchell K (1986) Identification of the DNA sequences controlling the expression of the MAT alpha locus of yeast. Proc Natl Acad Sci U S A 83(8):2320-4
Inokuchi K and Nakayama A (1991) Lack of a requirement for strict rotational alignment among transcription factor binding sites in yeast. Nucleic Acids Res 19(11):3099-103
Ray BL, et al. (1991) Heteroduplex formation and mismatch repair of the "stuck" mutation during mating-type switching in Saccharomyces cerevisiae. Mol Cell Biol 11(10):5372-80
Dubey DD, et al. (1991) Evidence suggesting that the ARS elements associated with silencers of the yeast mating-type locus HML do not function as chromosomal DNA replication origins. Mol Cell Biol 11(10):5346-55
Pillus L and Rine J (1989) Epigenetic inheritance of transcriptional states in S. cerevisiae. Cell 59(4):637-47
Bourens M, et al. (2009) Mutations in the Saccharomyces cerevisiae kinase Cbk1p lead to a fertility defect that can be suppressed by the absence of Brr1p or Mpt5p (Puf5p), proteins involved in RNA metabolism. Genetics 183(1):161-73
Weiffenbach B and Haber JE (1985) Homothallic switching of Saccharomyces cerevisiae mating type genes by using a donor containing a large internal deletion. Mol Cell Biol 5(8):2154-8
Caponigro G and Parker R (1996) mRNA turnover in yeast promoted by the MATalpha1 instability element. Nucleic Acids Res 24(21):4304-12
Rine J, et al. (1979) A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: evidence for and identification of cryptic mating-type loci. Genetics 93(4):877-901
Kayne PS, et al. (1988) Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell 55(1):27-39
Shore D, et al. (1984) Characterization of two genes required for the position-effect control of yeast mating-type genes. EMBO J 3(12):2817-23
Park EC and Szostak JW (1990) Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. Mol Cell Biol 10(9):4932-4
Tatchell K, et al. (1981) In vitro mutation analysis of the mating-type locus in yeast. Cell 27(1 Pt 2):25-35
Schnell R and Rine J (1986) A position effect on the expression of a tRNA gene mediated by the SIR genes in Saccharomyces cerevisiae. Mol Cell Biol 6(2):494-501
Mullen JR, et al. (1989) Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J 8(7):2067-75
Reynolds AE, et al. (1989) Time of replication of ARS elements along yeast chromosome III. Mol Cell Biol 9(10):4488-94
Parker R and Jacobson A (1990) Translation and a 42-nucleotide segment within the coding region of the mRNA encoded by the MAT alpha 1 gene are involved in promoting rapid mRNA decay in yeast. Proc Natl Acad Sci U S A 87(7):2780-4
Zill OA and Rine J (2008) Interspecies variation reveals a conserved repressor of {alpha}-specific genes in Saccharomyces yeasts. Genes Dev 22(12):1704-16
Hull CM and Johnson AD (1999) Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans. Science 285(5431):1271-5
McNally FJ and Rine J (1991) A synthetic silencer mediates SIR-dependent functions in Saccharomyces cerevisiae. Mol Cell Biol 11(11):5648-59
Aparicio OM, et al. (1991) Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell 66(6):1279-87
Tan S and Richmond TJ (1990) DNA binding-induced conformational change of the yeast transcriptional activator PRTF. Cell 62(2):367-77
Kushner PJ, et al. (1979) Control of yeast cell types by mobile genes: a test. Proc Natl Acad Sci U S A 76(10):5264-8
Haber JE, et al. (1993) Rapid kinetics of mismatch repair of heteroduplex DNA that is formed during recombination in yeast. Proc Natl Acad Sci U S A 90(8):3363-7
Sussel L and Shore D (1991) Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length. Proc Natl Acad Sci U S A 88(17):7749-
Mahoney DJ and Broach JR (1989) The HML mating-type cassette of Saccharomyces cerevisiae is regulated by two separate but functionally equivalent silencers. Mol Cell Biol 9(11):4621-30
Motwani T, et al. (2012) Sir3 and epigenetic inheritance of silent chromatin in Saccharomyces cerevisiae. Mol Cell Biol 32(14):2784-93
Koonin EV, et al. (1994) Yeast chromosome III: new gene functions. EMBO J 13(3):493-503
Lin CI, et al. (1990) Extragenic suppressors of mar2(sir3) mutations in Saccharomyces cerevisiae. Genetics 125(2):321-31
Johnson AD (1995) Molecular mechanisms of cell-type determination in budding yeast. Curr Opin Genet Dev 5(5):552-8
Steigele S, et al. (2007) Comparative analysis of structured RNAs in S. cerevisiae indicates a multitude of different functions. BMC Biol 5:25
Sengupta P and Cochran BH (1991) MAT alpha 1 can mediate gene activation by a-mating factor. Genes Dev 5(10):1924-34
Mead J, et al. (2002) Interactions of the Mcm1 MADS box protein with cofactors that regulate mating in yeast. Mol Cell Biol 22(13):4607-21