The 78 papers which experimentally study the biological roles of both TFs of the PCTFP (Ino2-Opi1)
Swift S and McGraw P (1995) INO1-100: an allele of the Saccharomyces cerevisiae INO1 gene that is transcribed without the action of the positive factors encoded by the INO2, INO4, SWI1, SWI2 and SWI3 genes. Nucleic Acids Res 23(8):1426-33
Wagner C, et al. (1999) Overproduction of the Opi1 repressor inhibits transcriptional activation of structural genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. Yeast 15(10A):843-54
Oshiro J, et al. (2000) Regulation of the DPP1-encoded diacylglycerol pyrophosphate (DGPP) phosphatase by inositol and growth phase. Inhibition of DGPP phosphatase activity by CDP-diacylglyceron and activation of phosphatidylserine synthase activity by DG
Hirsch JP and Henry SA (1986) Expression of the Saccharomyces cerevisiae inositol-1-phosphate synthase (INO1) gene is regulated by factors that affect phospholipid synthesis. Mol Cell Biol 6(10):3320-8
Li L, et al. (2009) Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells. Mol Biol Cell 20(17):3851-64
Brickner JH and Walter P (2004) Gene recruitment of the activated INO1 locus to the nuclear membrane. PLoS Biol 2(11):e342
Wagner C, et al. (2001) The negative regulator Opi1 of phospholipid biosynthesis in yeast contacts the pleiotropic repressor Sin3 and the transcriptional activator Ino2. Mol Microbiol 41(1):155-66
Ashburner BP and Lopes JM (1995) Regulation of yeast phospholipid biosynthetic gene expression in response to inositol involves two superimposed mechanisms. Proc Natl Acad Sci U S A 92(21):9722-6
Ko J, et al. (1994) Regulation of phosphatidylinositol:ceramide phosphoinositol transferase in Saccharomyces cerevisiae. J Bacteriol 176(16):5181-3
Ashburner BP and Lopes JM (1995) Autoregulated expression of the yeast INO2 and INO4 helix-loop-helix activator genes effects cooperative regulation on their target genes. Mol Cell Biol 15(3):1709-15
Nunez LR, et al. (2008) Cell wall integrity MAPK pathway is essential for lipid homeostasis. J Biol Chem 283(49):34204-17
Henry SA, et al. (2014) The response to inositol: Regulation of glycerolipid metabolism and stress response signaling in yeast. Chem Phys Lipids 180C():23-43
Kaadige MR and Lopes JM (2003) Opi1p, Ume6p and Sin3p control expression from the promoter of the INO2 regulatory gene via a novel regulatory cascade. Mol Microbiol 48(3):823-32
Iwanyshyn WM, et al. (2004) Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc. J Biol Chem 279(21):21976-83
Heyken WT, et al. (2005) Constitutive expression of yeast phospholipid biosynthetic genes by variants of Ino2 activator defective for interaction with Opi1 repressor. Mol Microbiol 56(3):696-707
Vaden DL, et al. (2001) Lithium and valproate decrease inositol mass and increase expression of the yeast INO1 and INO2 genes for inositol biosynthesis. J Biol Chem 276(18):15466-71
Graves JA and Henry SA (2000) Regulation of the yeast INO1 gene. The products of the INO2, INO4 and OPI1 regulatory genes are not required for repression in response to inositol. Genetics 154(4):1485-95
Hoppen J, et al. (2005) Comparative analysis of promoter regions containing binding sites of the heterodimeric transcription factor Ino2/Ino4 involved in yeast phospholipid biosynthesis. Yeast 22(8):601-13
Gardenour KR, et al. (2004) Identification of novel dominant INO2c mutants with an Opi- phenotype. Mol Microbiol 52(5):1271-80
Jiang F, et al. (1999) Cardiolipin synthase expression is essential for growth at elevated temperature and is regulated by factors affecting mitochondrial development. Mol Microbiol 31(1):373-9
Nohturfft A and Zhang SC (2009) Coordination of lipid metabolism in membrane biogenesis. Annu Rev Cell Dev Biol 25:539-66
Nikawa J and Kamiuto J (2004) The promoter of the yeast OPI1 regulatory gene. J Biosci Bioeng 97(6):369-73
Han SH, et al. (2005) Regulation of the PIS1-encoded phosphatidylinositol synthase in Saccharomyces cerevisiae by zinc. J Biol Chem 280(32):29017-24
Shirra MK, et al. (2005) The Snf1 protein kinase and Sit4 protein phosphatase have opposing functions in regulating TATA-binding protein association with the Saccharomyces cerevisiae INO1 promoter. Genetics 169(4):1957-72
Pascual F, et al. (2013) PAH1-encoded Phosphatidate Phosphatase Plays a Role in the Growth Phase- and Inositol-mediated Regulation of Lipid Synthesis in Saccharomyces cerevisiae. J Biol Chem 288(50):35781-92
Gururaj C, et al. (2013) Orm proteins integrate multiple signals to maintain sphingolipid homeostasis. J Biol Chem 288(28):20453-63
Grauslund M, et al. (1999) Expression of GUT1, which encodes glycerol kinase in Saccharomyces cerevisiae, is controlled by the positive regulators Adr1p, Ino2p and Ino4p and the negative regulator Opi1p in a carbon source-dependent fashion. Nucleic Acids
Chumnanpuen P, et al. (2012) Integrated analysis of transcriptome and lipid profiling reveals the co-influences of inositol-choline and Snf1 in controlling lipid biosynthesis in yeast. Mol Genet Genomics 287(7):541-54
Howe AG and McMaster CR (2001) Regulation of vesicle trafficking, transcription, and meiosis: lessons learned from yeast regarding the disparate biologies of phosphatidylcholine. Biochim Biophys Acta 1534(2-3):65-77
Li Z and Brendel M (1993) Co-regulation with genes of phospholipid biosynthesis of the CTR/HNM1-encoded choline/nitrogen mustard permease in Saccharomyces cerevisiae. Mol Gen Genet 241(5-6):680-4
Wilson JD, et al. (2011) Yet1p-Yet3p interacts with Scs2p-Opi1p to regulate ER localization of the Opi1p repressor. Mol Biol Cell 22(9):1430-9
Carman GM and Han GS (2011) Regulation of phospholipid synthesis in the yeast Saccharomyces cerevisiae. Annu Rev Biochem 80():859-83
Klug L and Daum G (2014) Yeast lipid metabolism at a glance. FEMS Yeast Res 14(3):369-388
de Kroon AI, et al. (2013) Checks and balances in membrane phospholipid class and acyl chain homeostasis, the yeast perspective. Prog Lipid Res 52(4):374-94
Kumme J, et al. (2008) Dimerization of yeast transcription factors Ino2 and Ino4 is regulated by precursors of phospholipid biosynthesis mediated by Opi1 repressor. Curr Genet 54(1):35-45
Bachhawat N, et al. (1995) Functional characterization of an inositol-sensitive upstream activation sequence in yeast. A cis-regulatory element responsible for inositol-choline mediated regulation of phospholipid biosynthesis. J Biol Chem 270(42):25087-95
Singh KK, et al. (2004) Genome-wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiae. Ann N Y Acad Sci 1011:284-98
Reynolds TB (2006) The Opi1p transcription factor affects expression of FLO11, mat formation, and invasive growth in Saccharomyces cerevisiae. Eukaryot Cell 5(8):1266-75
Hofbauer HF, et al. (2014) Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids. Dev Cell 29(6):729-39
Anderson MS and Lopes JM (1996) Carbon source regulation of PIS1 gene expression in Saccharomyces cerevisiae involves the MCM1 gene and the two-component regulatory gene, SLN1. J Biol Chem 271(43):26596-601
Jesch SA, et al. (2005) Genome-wide analysis reveals inositol, not choline, as the major effector of Ino2p-Ino4p and unfolded protein response target gene expression in yeast. J Biol Chem 280(10):9106-18
Hasslacher M, et al. (1993) Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism. J Biol Chem 268(15):10946-52
Chumnanpuen P, et al. (2013) Integrated analysis, transcriptome-lipidome, reveals the effects of INO-level (INO2 and INO4) on lipid metabolism in yeast. BMC Syst Biol 7(Suppl 3):S7
Soto A and Carman GM (2008) Regulation of the Saccharomyces cerevisiae CKI1-encoded Choline Kinase by Zinc Depletion. J Biol Chem 283(15):10079-88
Lopes JM and Henry SA (1991) Interaction of trans and cis regulatory elements in the INO1 promoter of Saccharomyces cerevisiae. Nucleic Acids Res 19(14):3987-94
Carman GM (2011) The discovery of the fat-regulating phosphatidic acid phosphatase gene. Front Biol 6(3):172-176
Sharma M, et al. (2011) Inhibition of phospholipid biosynthesis decreases the activity of the tombusvirus replicase and alters the subcellular localization of replication proteins. Virology 415(2):141-52
Kaadige MR and Lopes JM (2006) Analysis of Opi1p repressor mutants. Curr Genet 49(1):30-8
Henry SA, et al. (2012) Metabolism and Regulation of Glycerolipids in the Yeast Saccharomyces cerevisiae. Genetics 190(2):317-49
Zhong Q and Greenberg ML (2003) Regulation of phosphatidylglycerophosphate synthase by inositol in Saccharomyces cerevisiae is not at the level of PGS1 mRNA abundance. J Biol Chem 278(36):33978-84
Santiago TC and Mamoun CB (2003) Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. J Biol Chem 278(40):38723-30
Barajas D, et al. (2014) Tombusviruses upregulate phospholipid biosynthesis via interaction between p33 replication protein and yeast lipid sensor proteins during virus replication in yeast. Virology 471-473():72-80
Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31
Homann MJ, et al. (1987) Coordinate regulation of phospholipid biosynthesis by serine in Saccharomyces cerevisiae. J Bacteriol 169(7):3276-80
Carman GM and Henry SA (2007) Phosphatidic acid plays a central role in the transcriptional regulation of glycerophospholipid synthesis in Saccharomyces cerevisiae. J Biol Chem 282(52):37293-7
Bailis AM, et al. (1987) The membrane-associated enzyme phosphatidylserine synthase is regulated at the level of mRNA abundance. Mol Cell Biol 7(1):167-76
Lamping E, et al. (1991) Coordinate regulation of phosphatidylserine decarboxylase in Saccharomyces cerevisiae. J Bacteriol 173(20):6432-7
Shen H and Dowhan W (1997) Regulation of phospholipid biosynthetic enzymes by the level of CDP-diacylglycerol synthase activity. J Biol Chem 272(17):11215-20
Carman GM (2005) Regulation of phospholipid synthesis in yeast by zinc. Biochem Soc Trans 33(Pt 5):1150-3
Bailis AM, et al. (1992) Cis and trans regulatory elements required for regulation of the CHO1 gene of Saccharomyces cerevisiae. Nucleic Acids Res 20(6):1411-8
Chen M, et al. (2007) Transcriptional regulation of yeast phospholipid biosynthetic genes. Biochim Biophys Acta 1771(3):310-21
Baile MG, et al. (2014) The topology and regulation of cardiolipin biosynthesis and remodeling in yeast. Chem Phys Lipids 179():25-31
Loewen CJ (2012) Lipids as conductors in the orchestra of life. F1000 Biol Rep 4():4
Jackson JC and Lopes JM (1996) The yeast UME6 gene is required for both negative and positive transcriptional regulation of phospholipid biosynthetic gene expression. Nucleic Acids Res 24(7):1322-9
Grigat M, et al. (2012) Multiple histone deacetylases are recruited by corepressor Sin3 and contribute to gene repression mediated by Opi1 regulator of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 287(6):461-72
Schuck S, et al. (2009) Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J Cell Biol 187(4):525-36
Jesch SA, et al. (2006) Multiple endoplasmic reticulum-to-nucleus signaling pathways coordinate phospholipid metabolism with gene expression by distinct mechanisms. J Biol Chem 281(33):24070-83
Kersting MC, et al. (2004) Regulation of the yeast EKI1-encoded ethanolamine kinase by inositol and choline. J Biol Chem 279(34):35353-9
Nielsen J (2009) Systems biology of lipid metabolism: from yeast to human. FEBS Lett 583(24):3905-13
Lai K and McGraw P (1994) Dual control of inositol transport in Saccharomyces cerevisiae by irreversible inactivation of permease and regulation of permease synthesis by INO2, INO4, and OPI1. J Biol Chem 269(3):2245-51
Dzugasova V, et al. (1998) Phosphatidylglycerolphosphate synthase encoded by the PEL1/PGS1 gene in Saccharomyces cerevisiae is localized in mitochondria and its expression is regulated by phospholipid precursors. Curr Genet 34(4):297-302
Mas S, et al. (2007) A comparison of direct infusion MS and GC-MS for metabolic footprinting of yeast mutants. Biotechnol Bioeng 96(5):1014-22
Young BP, et al. (2010) Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism. Science 329(5995):1085-8
Cok SJ, et al. (1998) Transcription of INO2 and INO4 is regulated by the state of protein N-myristoylation in Saccharomyces cerevisiae. Nucleic Acids Res 26(12):2865-72
Jaschke Y, et al. (2011) Pleiotropic corepressors Sin3 and Ssn6 interact with repressor Opi1 and negatively regulate transcription of genes required for phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 285(2):91-100
Fukuda R (2013) Metabolism of Hydrophobic Carbon Sources and Regulation of It in n-Alkane-Assimilating Yeast Yarrowia lipolytica. Biosci Biotechnol Biochem 77(6):1149-1154
Lavoie H, et al. (2009) Rearrangements of the transcriptional regulatory networks of metabolic pathways in fungi. Curr Opin Microbiol 12(6):655-63
Sugimoto H, et al. (2008) Transcriptional regulation of phosphatidylcholine biosynthesis. Prog Lipid Res 47(3):204-20