The 57 papers which experimentally study the biological roles of both TFs of the PCTFP (Oaf1-Pip2)
Gurvitz A, et al. (1998) Peroxisomal Delta3-cis-Delta2-trans-enoyl-CoA isomerase encoded by ECI1 is required for growth of the yeast Saccharomyces cerevisiae on unsaturated fatty acids. J Biol Chem 273(47):31366-74
Gurvitz A, et al. (2001) Peroxisomal degradation of trans-unsaturated fatty acids in the yeast Saccharomyces cerevisiae. J Biol Chem 276(2):895-903
Karpichev IV and Small GM (1998) Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Mol Cell Biol 18(11):6560-70
Zheng J, et al. (2010) Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol 6():420
Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60
Turcotte B, et al. (2010) Transcriptional regulation of nonfermentable carbon utilization in budding yeast. FEMS Yeast Res 10(1):2-13
Black PN and Dirusso CC (2007) Yeast acyl-CoA synthetases at the crossroads of fatty acid metabolism and regulation. Biochim Biophys Acta 1771(3):286-98
Knijnenburg TA, et al. (2011) A regression model approach to enable cell morphology correction in high-throughput flow cytometry. Mol Syst Biol 7():531
Legras JL, et al. (2010) Activation of Two Different Resistance Mechanisms in Saccharomyces cerevisiae upon Exposure to Octanoic and Decanoic Acids. Appl Environ Microbiol 76(22):7526-35
Karpichev IV and Small GM (2000) Evidence for a novel pathway for the targeting of a Saccharomyces cerevisiae peroxisomal protein belonging to the isomerase/hydratase family. J Cell Sci 113 ( Pt 3)():533-44
Hiltunen JK, et al. (2003) The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 27(1):35-64
Zhang J, et al. (2010) Systems biology of energy homeostasis in yeast. Curr Opin Microbiol 13(3):382-8
Karpichev IV, et al. (2008) Binding characteristics and regulatory mechanisms of the transcription factors controlling oleate-responsive genes in Saccharomyces cerevisiae. J Biol Chem 283(16):10264-75
Smith JJ, et al. (2007) Transcriptional responses to fatty acid are coordinated by combinatorial control. Mol Syst Biol 3():115
Cavalieri D, et al. (2009) Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis. BMC Genomics 10():596
Rottensteiner H, et al. (2003) Saccharomyces cerevisiae Pip2p-Oaf1p regulates PEX25 transcription through an adenine-less ORE. Eur J Biochem 270(9):2013-22
Ratushny AV, et al. (2008) Control of transcriptional variability by overlapping feed-forward regulatory motifs. Biophys J 95(8):3715-23
Nielsen J (2009) Systems biology of lipid metabolism: from yeast to human. FEBS Lett 583(24):3905-13
MacPherson S, et al. (2006) A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol Mol Biol Rev 70(3):583-604
Trzcinska-Danielewicz J, et al. (2008) Yeast transcription factor Oaf1 forms homodimer and induces some oleate-responsive genes in absence of Pip2. Biochem Biophys Res Commun 374(4):763-6
Bussereau F, et al. (2006) The Kluyveromyces lactis repertoire of transcriptional regulators. FEMS Yeast Res 6(3):325-35
Gurvitz A, et al. (2009) Avoiding unscheduled transcription in shared promoters: Saccharomyces cerevisiae Sum1p represses the divergent gene pair SPS18-SPS19 through a midsporulation element (MSE). FEMS Yeast Res 9(6):821-31
Gurvitz A, et al. (1997) Regulation of the yeast SPS19 gene encoding peroxisomal 2,4-dienoyl-CoA reductase by the transcription factors Pip2p and Oaf1p: beta-oxidation is dispensable for Saccharomyces cerevisiae sporulation in acetate medium. Mol Microbio
Schrader M and Fahimi HD (2006) Growth and division of peroxisomes. Int Rev Cytol 255:237-90
Gurvitz A, et al. (2000) Adr1p-dependent regulation of the oleic acid-inducible yeast gene SPS19 encoding the peroxisomal beta-oxidation auxiliary enzyme 2,4-dienoyl-CoA reductase. Mol Cell Biol Res Commun 4(2):81-9
Karpichev IV, et al. (1997) A complex containing two transcription factors regulates peroxisome proliferation and the coordinate induction of beta-oxidation enzymes in Saccharomyces cerevisiae. Mol Cell Biol 17(1):69-80
Gurvitz A and Rottensteiner H (2006) The biochemistry of oleate induction: transcriptional upregulation and peroxisome proliferation. Biochim Biophys Acta 1763(12):1392-402
Tibbetts A, et al. (2002) Yeast mitochondrial oxodicarboxylate transporters are important for growth on oleic acid. Arch Biochem Biophys 406(1):96-104
Beskow A and Wright AP (2006) Comparative analysis of regulatory transcription factors in Schizosaccharomyces pombe and budding yeasts. Yeast 23(13):929-35
Longen S, et al. (2009) Systematic analysis of the twin cx(9)c protein family. J Mol Biol 393(2):356-68
Chang YW, et al. (2008) Roles of cis- and trans-changes in the regulatory evolution of genes in the gluconeogenic pathway in yeast. Mol Biol Evol 25(9):1863-75
Wan Y, et al. (2013) Role of the repressor Oaf3p in the recruitment of transcription factors and chromatin dynamics during the oleate response. Biochem J 449(2):507-17
Piskacek S, et al. (2007) Nine-amino-acid transactivation domain: Establishment and prediction utilities. Genomics 89(6):756-68
Zhao Y, et al. (2008) Development of a Novel Oligonucleotide Array-Based Transcription Factor Assay Platform for Genome-Wide Active Transcription Factor Profiling in Saccharomyces cerevisiae. J Proteome Res 7(3):1315-1325
Rottensteiner H, et al. (1997) A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Eur J Biochem 247(3):776-83
Chumnanpuen P, et al. (2013) Integrated analysis, transcriptome-lipidome, reveals the effects of INO-level (INO2 and INO4) on lipid metabolism in yeast. BMC Syst Biol 7(Suppl 3):S7
Gurvitz A, et al. (2001) Saccharomyces cerevisiae Adr1p governs fatty acid beta-oxidation and peroxisome proliferation by regulating POX1 and PEX11. J Biol Chem 276(34):31825-30
Luo Y, et al. (1996) Purification, identification, and properties of a Saccharomyces cerevisiae oleate-activated upstream activating sequence-binding protein that is involved in the activation of POX1. J Biol Chem 271(20):12068-75
Jothi R, et al. (2009) Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture. Mol Syst Biol 5:294
Rottensteiner H, et al. (2002) The peroxisomal transporter gene ANT1 is regulated by a deviant oleate response element (ORE): characterization of the signal for fatty acid induction. Biochem J 365(Pt 1):109-17
Kal AJ, et al. (1999) Dynamics of gene expression revealed by comparison of serial analysis of gene expression transcript profiles from yeast grown on two different carbon sources. Mol Biol Cell 10(6):1859-72
Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31
Poopanitpan N, et al. (2010) An ortholog of farA of Aspergillus nidulans is implicated in the transcriptional activation of genes involved in fatty acid utilization in the yeast Yarrowia lipolytica. Biochem Biophys Res Commun 402(4):731-5
Ratnakumar S and Young ET (2010) Snf1 dependence of peroxisomal gene expression is mediated by Adr1. J Biol Chem 285(14):10703-14
Ratushny AV, et al. (2012) Asymmetric positive feedback loops reliably control biological responses. Mol Syst Biol 8():577
Gurvitz A, et al. (1999) A novel element in the promoter of the Saccharomyces cerevisiae gene SPS19 enhances ORE-dependent up-regulation in oleic acid and is essential for de-repression. Mol Gen Genet 262(3):481-92
Rottensteiner H, et al. (2003) Saccharomyces cerevisiae PIP2 mediating oleic acid induction and peroxisome proliferation is regulated by Adr1p and Pip2p-Oaf1p. J Biol Chem 278(30):27605-11
Todd RB and Andrianopoulos A (1997) Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif. Fungal Genet Biol 21(3):388-405
Morozov AV and Siggia ED (2007) Connecting protein structure with predictions of regulatory sites. Proc Natl Acad Sci U S A 104(17):7068-73
Xu T, et al. (2012) A potent plant-derived antifungal acetylenic acid mediates its activity by interfering with fatty acid homeostasis. Antimicrob Agents Chemother 56(6):2894-907
Lavoie H, et al. (2009) Rearrangements of the transcriptional regulatory networks of metabolic pathways in fungi. Curr Opin Microbiol 12(6):655-63
Baumgartner U, et al. (1999) Functional analysis of the Zn(2)Cys(6) transcription factors Oaf1p and Pip2p. Different roles in fatty acid induction of beta-oxidation in Saccharomyces cerevisiae. J Biol Chem 274(32):22208-16
Phelps C, et al. (2006) Fungi and animals may share a common ancestor to nuclear receptors. Proc Natl Acad Sci U S A 103(18):7077-81
Ramirez MA and Lorenz MC (2009) The transcription factor homolog CTF1 regulates {beta}-oxidation in Candida albicans. Eukaryot Cell 8(10):1604-14
Fukuda R (2013) Metabolism of Hydrophobic Carbon Sources and Regulation of It in n-Alkane-Assimilating Yeast Yarrowia lipolytica. Biosci Biotechnol Biochem 77(6):1149-1154
Lockshon D, et al. (2007) The sensitivity of yeast mutants to oleic Acid implicates the peroxisome and other processes in membrane function. Genetics 175(1):77-91
Lee SI, et al. (2009) Learning a prior on regulatory potential from eQTL data. PLoS Genet 5(1):e1000358