| Anderson JB, et al. (2004) Haploidy, diploidy and evolution of antifungal drug resistance in Saccharomyces cerevisiae. Genetics 168(4):1915-23 |
| Mamnun YM, et al. (2002) The yeast zinc finger regulators Pdr1p and Pdr3p control pleiotropic drug resistance (PDR) as homo- and heterodimers in vivo. Mol Microbiol 46(5):1429-40 |
| Kolaczkowski M, et al. (1998) In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network. Microb Drug Resist 4(3):143-58 |
| Bailly-Bechet M, et al. (2010) Inference of sparse combinatorial-control networks from gene-expression data: a message passing approach. BMC Bioinformatics 11():355 |
| Balgi AD and Roberge M (2009) Screening for chemical inhibitors of heterologous proteins expressed in yeast using a simple growth-restoration assay. Methods Mol Biol 486:125-37 |
| Song M, et al. (2009) Discrete dynamical system modelling for gene regulatory networks of 5-hydroxymethylfurfural tolerance for ethanologenic yeast. IET Syst Biol 3(3):203 |
| Kolaczkowski M and Goffeau A (1997) Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance. Pharmacol Ther 76(1-3):219-42 |
| Izumikawa K, et al. (2003) Function of Candida glabrata ABC transporter gene, PDH1. Yeast 20(3):249-61 |
| Moye-Rowley WS (2003) Transcriptional control of multidrug resistance in the yeast Saccharomyces. Prog Nucleic Acid Res Mol Biol 73():251-79 |
| Martens JA, et al. (1996) Transcriptional activation by yeast PDR1p is inhibited by its association with NGG1p/ADA3p. J Biol Chem 271(27):15884-90 |
| Rojas M, et al. (2008) Selective inhibition of yeast regulons by daunorubicin: a transcriptome-wide analysis. BMC Genomics 9:358 |
| Coste AT, et al. (2008) Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae. Microbiology 154(Pt 5):1491-501 |
| Huang Z, et al. (2013) A functional variomics tool for discovering drug-resistance genes and drug targets. Cell Rep 3(2):577-85 |
| Jensen AN, et al. (2014) Improper protein trafficking contributes to artemisinin sensitivity in cells lacking the KDAC Rpd3p. FEBS Lett 588(21):4018-25 |
| Leverentz MK and Reece RJ (2006) Phosphorylation of Zn(II)2Cys6 proteins: a cause or effect of transcriptional activation? Biochem Soc Trans 34(Pt 5):794-7 |
| Michalkova-Papajova D, et al. (2000) Role of the PDR gene network in yeast susceptibility to the antifungal antibiotic mucidin. Antimicrob Agents Chemother 44(2):418-20 |
| Gulshan K, et al. (2008) Evidence for the bifunctional nature of mitochondrial phosphatidylserine decarboxylase: role in Pdr3-dependent retrograde regulation of PDR5 expression. Mol Cell Biol 28(19):5851-64 |
| Balazfyova Z, et al. (2013) Gain-of-function mutation in the KlPDR1 gene encoding multidrug resistance regulator in Kluyveromyces lactis. Yeast 30(2):71-80 |
| Teixeira MC, et al. (2006) Early transcriptional response of Saccharomyces cerevisiae to stress imposed by the herbicide 2,4-dichlorophenoxyacetic acid. FEMS Yeast Res 6(2):230-48 |
| Salin H, et al. (2008) Structure and properties of transcriptional networks driving selenite stress response in yeasts. BMC Genomics 9:333 |
| Klimova N, et al. (2014) Phenotypic Analysis of a Family of Transcriptional Regulators, the Zinc Cluster Proteins, in the Human Fungal Pathogen Candida glabrata. G3 (Bethesda) () |
| Hallstrom TC and Moye-Rowley WS (2000) Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. J Biol Chem 275(48):37347-56 |
| Klein C, et al. (2011) ABC proteins in yeast and fungal pathogens. Essays Biochem 50(1):101-19 |
| Delahodde A, et al. (1995) Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance. Mol Cell Biol 15(8):4043-51 |
| Hanna R, et al. (2013) Characterizing the laulimalide-peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae. Mol Biosyst 10(1):110-6 |
| Hallstrom TC, et al. (2001) Coordinate control of sphingolipid biosynthesis and multidrug resistance in Saccharomyces cerevisiae. J Biol Chem 276(26):23674-80 |
| Ling H, et al. (2015) Engineering transcription factors to improve tolerance against alkane biofuels in Saccharomyces cerevisiae. Biotechnol Biofuels 8():231 |
| Hellauer K, et al. (2002) Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene encoding a multidrug transporter. J Biol Chem 277(20):17671-6 |
| Zhao Y, et al. (2008) Development of a Novel Oligonucleotide Array-Based Transcription Factor Assay Platform for Genome-Wide Active Transcription Factor Profiling in Saccharomyces cerevisiae. J Proteome Res 7(3):1315-1325 |
| Coorey NV, et al. (2015) Pleiotropic drug-resistance attenuated genomic library improves elucidation of drug mechanisms. Mol Biosyst 11(11):3129-36 |
| Zheng J, et al. (2010) Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol 6():420 |
| Lamping E, et al. (2007) Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae. Eukaryot Cell 6(7):1150-65 |
| Zhang X, et al. (2001) Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. J Biol Chem 276(12):8812-9 |
| Gaskova D, et al. (2002) Monitoring the kinetics and performance of yeast membrane ABC transporters by diS-C3(3) fluorescence. Int J Biochem Cell Biol 34(8):931-7 |
| Lai FJ, et al. (2014) A comprehensive performance evaluation on the prediction results of existing cooperative transcription factors identification algorithms. BMC Syst Biol 8 Suppl 4():S9 |
| Simonics T, et al. (2000) Isolation and molecular characterization of the carboxy-terminal pdr3 mutants in Saccharomyces cerevisiae. Curr Genet 38(5):248-55 |
| Srikanth CV, et al. (2005) Acetaminophen toxicity and resistance in the yeast Saccharomyces cerevisiae. Microbiology 151(Pt 1):99-111 |
| Keeven J, et al. (2002) PDR2 Gain-of-function mutations eliminate the need for Pdr1 and require the UBP6 product for resistance to translational inhibitors. Curr Genet 41(1):11-9 |
| Banerjee D, et al. (2008) Responses of pathogenic and nonpathogenic yeast species to steroids reveal the functioning and evolution of multidrug resistance transcriptional networks. Eukaryot Cell 7(1):68-77 |
| Cui Z, et al. (1999) Functional analysis of the promoter of the yeast SNQ2 gene encoding a multidrug resistance transporter that confers the resistance to 4-nitroquinoline N-oxide. Biosci Biotechnol Biochem 63(1):162-7 |
| Dexter D, et al. (1994) Mutations in the yeast PDR3, PDR4, PDR7 and PDR9 pleiotropic (multiple) drug resistance loci affect the transcript level of an ATP binding cassette transporter encoding gene, PDR5. Genetics 136(2):505-15 |
| Borecka-Melkusova S, et al. (2008) RPD3 and ROM2 are required for multidrug resistance in Saccharomyces cerevisiae. FEMS Yeast Res 8(3):414-24 |
| Babbitt GA (2010) Relaxed selection against accidental binding of transcription factors with conserved chromatin contexts. Gene 466(1-2):43-8 |
| Shahi P, et al. (2007) Negative transcriptional regulation of multidrug resistance gene expression by an Hsp70 protein. J Biol Chem 282(37):26822-31 |
| Aburai N, et al. (2013) Pisiferdiol restores the growth of a mutant yeast suffering from hyperactivated Ca2+ signalling through calcineurin inhibition. FEMS Yeast Res 13(1):16-22 |
| Hill P, et al. (2003) Recapitulation in Saccharomyces cerevisiae of cytochrome b mutations conferring resistance to atovaquone in Pneumocystis jiroveci. Antimicrob Agents Chemother 47(9):2725-31 |
| Zhu Y and Xiao W (2004) Pdr3 is required for DNA damage induction of MAG1 and DDI1 via a bi-directional promoter element. Nucleic Acids Res 32(17):5066-75 |
| Le Crom S, et al. (2002) New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Mol Cell Biol 22(8):2642-9 |
| Garcia-Lopez MC, et al. (2010) Overexpression of SNG1 causes 6-azauracil resistance in Saccharomyces cerevisiae. Curr Genet 56(3):251-63 |
| Best HA, et al. (2013) Laulimalide and peloruside A inhibit mitosis of Saccharomyces cerevisiae by preventing microtubule depolymerisation-dependent steps in chromosome separation and nuclear positioning. Mol Biosyst 9(11):2842-2852 |
| Balkova K, et al. (2009) Functional analysis of the Kluyveromyces lactis PDR1 gene. FEMS Yeast Res 9(2):321-7 |
| Temple MD, et al. (2005) Complex cellular responses to reactive oxygen species. Trends Cell Biol 15(6):319-26 |
| Kozovska Z, et al. (2004) Yeast strains designed for screening of reversal agents and genetic suppressors of multidrug resistance. Int J Antimicrob Agents 24(4):386-92 |
| Voelker DR (2004) Genetic analysis of intracellular aminoglycerophospholipid traffic. Biochem Cell Biol 82(1):156-69 |
| Decottignies A, et al. (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J Biol Chem 273(20):12612-22 |
| Mahe Y, et al. (1996) The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3. Mol Microbiol 20(1):109-17 |
| Goffa E, et al. (2011) A yeast cell-based system for screening Candida glabrata multidrug resistance reversal agents and selection of loss-of-function pdr1 mutants. FEMS Yeast Res 11(2):155-9 |
| Jarmula A, et al. (2011) [Efflux-mediated antimicrobial multidrug resistance.] Postepy Hig Med Dosw (Online) 65():216-227 |
| Yang X, et al. (2001) Functional isolation of the Candida albicans FCR3 gene encoding a bZip transcription factor homologous to Saccharomyces cerevisiae Yap3p. Yeast 18(13):1217-25 |
| Kolaczkowski M, et al. (2004) Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae. Eukaryot Cell 3(4):880-92 |
| Beskow A and Wright AP (2006) Comparative analysis of regulatory transcription factors in Schizosaccharomyces pombe and budding yeasts. Yeast 23(13):929-35 |
| Miranda MN, et al. (2010) The serine/threonine protein phosphatase Sit4p activates multidrug resistance in Saccharomyces cerevisiae. FEMS Yeast Res 10(6):674-86 |
| Kihara A and Igarashi Y (2004) Cross talk between sphingolipids and glycerophospholipids in the establishment of plasma membrane asymmetry. Mol Biol Cell 15(11):4949-59 |
| Teixeira MC, et al. (2012) Increased expression of the yeast multidrug resistance ABC transporter Pdr18 leads to increased ethanol tolerance and ethanol production in high gravity alcoholic fermentation. Microb Cell Fact 11(1):98 |
| Banerjee D, et al. (2004) Genome-wide expression profile of steroid response in Saccharomyces cerevisiae. Biochem Biophys Res Commun 317(2):406-13 |
| Chinen T, et al. (2014) Construction of a genetic analysis-available multidrug sensitive yeast strain by disruption of the drug efflux system and conditional repression of the membrane barrier system. J Gen Appl Microbiol 60(4):160-2 |
| Nourani A, et al. (1997) Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transporters. Mol Cell Biol 17(9):5453-60 |
| Nyfeler B, et al. (2012) Identification of elongation factor g as the conserved cellular target of argyrin B. PLoS One 7(9):e42657 |
| Zhang M, et al. (2010) Creation of a hyperpermeable yeast strain to genotoxic agents through combined inactivation of PDR and CWP genes. Toxicol Sci 113(2):401-11 |
| Shahi P and Moye-Rowley WS (2009) Coordinate control of lipid composition and drug transport activities is required for normal multidrug resistance in fungi. Biochim Biophys Acta 1794(5):852-9 |
| Nishida-Aoki N, et al. (2015) Activation of the mitochondrial signaling pathway in response to organic solvent stress in yeast. Curr Genet 61(2):153-164 |
| Katzmann DJ, et al. (1996) Multiple Pdr1p/Pdr3p binding sites are essential for normal expression of the ATP binding cassette transporter protein-encoding gene PDR5. J Biol Chem 271(38):23049-54 |
| Bauer BE, et al. (1999) Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim Biophys Acta 1461(2):217-36 |
| Ma M and Liu ZL (2010) Quantitative transcription dynamic analysis reveals candidate genes and key regulators for ethanol tolerance in Saccharomyces cerevisiae. BMC Microbiol 10():169 |
| Wolfger H, et al. (2001) Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification. Res Microbiol 152(3-4):375-89 |
| Pastor-Flores D, et al. (2013) PIF-Pocket as a Target for C. albicans Pkh Selective Inhibitors. ACS Chem Biol 8(10):2283-92 |
| Witek S, et al. (1998) "Soft" lysosomotropic compounds as new substrates of the yeast PDR network. Folia Microbiol (Praha) 43(2):214-6 |
| Talibi D and Raymond M (1999) Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdr1 pdr3 mutation in Saccharomyces cerevisiae. J Bacteriol 181(1):231-40 |
| Hallstrom TC, et al. (1998) Regulation of transcription factor Pdr1p function by an Hsp70 protein in Saccharomyces cerevisiae. Mol Cell Biol 18(3):1147-55 |
| Katzmann DJ, et al. (1995) Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae. Mol Cell Biol 15(12):6875-83 |
| Todd RB and Andrianopoulos A (1997) Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif. Fungal Genet Biol 21(3):388-405 |
| Plowright AT, et al. (2002) Transcriptional response pathways in a yeast strain sensitive to saframycin a and a more potent analog: evidence for a common basis of activity. Chem Biol 9(5):607-18 |
| Delahodde A, et al. (2001) Pse1/Kap121-dependent nuclear localization of the major yeast multidrug resistance (MDR) transcription factor Pdr1. Mol Microbiol 39(2):304-12 |
| Miura F, et al. (2001) Differential display analysis of mutants for the transcription factor Pdr1p regulating multidrug resistance in the budding yeast. FEBS Lett 505(1):103-8 |
| Sekigawa M, et al. (2010) Comprehensive screening of human genes with inhibitory effects on yeast growth and validation of a yeast cell-based system for screening chemicals. J Biomol Screen 15(4):368-78 |
| Anderson JB, et al. (2006) Antagonism between Two Mechanisms of Antifungal Drug Resistance. Eukaryot Cell 5(8):1243-51 |
| Galdieri L, et al. (2012) Facilitated assembly of the preinitiation complex by separated tail and head/middle modules of the mediator. J Mol Biol 415(3):464-74 |
| Goffeau A (2008) Drug resistance: the fight against fungi. Nature 452(7187):541-2 |
| Nawrocki A, et al. (2001) The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance. Proteomics 1(8):1022-32 |
| Kitagaki H and Kitamoto K (2013) Breeding research on sake yeasts in Japan: history, recent technological advances, and future perspectives. Annu Rev Food Sci Technol 4():215-35 |
| Lucchini G, et al. (1979) Nuclear inheritance of resistance to antimycin A in Saccharomyces cerevisiae. Mol Gen Genet 177(1):139-43 |
| Klug L and Daum G (2014) Yeast lipid metabolism at a glance. FEMS Yeast Res 14(3):369-388 |
| Hnatova M, et al. (2003) Cross-resistance to strobilurin fungicides in mitochondrial and nuclear mutants of Saccharomyces cerevisiae. Folia Microbiol (Praha) 48(4):496-500 |
| Jungwirth H and Kuchler K (2006) Yeast ABC transporters-- a tale of sex, stress, drugs and aging. FEBS Lett 580(4):1131-8 |
| Akache B, et al. (2004) Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae. J Biol Chem 279(27):27855-60 |
| Hu F, et al. (2012) Key cytomembrane ABC transporters of Saccharomyces cerevisiae fail to improve the tolerance to D-limonene. Biotechnol Lett 34(8):1505-9 |
| Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31 |
| Millson SH, et al. (2010) A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta. Biochem Pharmacol 79(11):1581-8 |
| Suzuki T and Iwahashi Y (2016) Acetylated Deoxynivalenol Generates Differences of Gene Expression that Discriminate Trichothecene Toxicity. Toxins (Basel) 8(2) |
| Legras JL, et al. (2010) Activation of Two Different Resistance Mechanisms in Saccharomyces cerevisiae upon Exposure to Octanoic and Decanoic Acids. Appl Environ Microbiol 76(22):7526-35 |
| Cary GA, et al. (2014) Identification and characterization of a drug-sensitive strain enables puromycin-based translational assays in Saccharomyces cerevisiae. Yeast 31(5):167-78 |
| Lelandais G and Devaux F (2010) Comparative functional genomics of stress responses in yeasts. OMICS 14(5):501-15 |
| Takacova M, et al. (2002) Isolation, heterological cloning and sequencing of the RPL28 gene in Kluyveromyces lactis. Curr Genet 42(1):21-6 |
| Hallstrom TC and Moye-Rowley WS (1998) Divergent transcriptional control of multidrug resistance genes in Saccharomyces cerevisiae. J Biol Chem 273(4):2098-104 |
| Delaveau T, et al. (1994) PDR3, a new yeast regulatory gene, is homologous to PDR1 and controls the multidrug resistance phenomenon. Mol Gen Genet 244(5):501-11 |
| Erb I and van Nimwegen E (2011) Transcription factor binding site positioning in yeast: proximal promoter motifs characterize tata-less promoters. PLoS One 6(9):e24279 |
| Kolaczkowski M, et al. (2009) Modulation of the antifungal activity of new medicinal plant extracts active on Candida glabrata by the major transporters and regulators of the pleiotropic drug-resistance network in Saccharomyces cerevisiae. Microb Drug Res |
| Yibmantasiri P, et al. (2013) Networks of genes modulating the pleiotropic drug response in Saccharomyces cerevisiae. Mol Biosyst 10(1):128-37 |
| Cannon RD, et al. (2009) Efflux-mediated antifungal drug resistance. Clin Microbiol Rev 22(2):291-321, Table of Contents |
| Gordan R, et al. (2011) Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol 12(12):R125 |
| Teixeira MC, et al. (2008) Yeast adaptation to mancozeb involves the up-regulation of FLR1 under the coordinate control of Yap1, Rpn4, Pdr3, and Yrr1. Biochem Biophys Res Commun 367(2):249-55 |
| Singh-Babak SD, et al. (2012) A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae. Mol Biosyst 8(10):2575-84 |
| Morozov AV and Siggia ED (2007) Connecting protein structure with predictions of regulatory sites. Proc Natl Acad Sci U S A 104(17):7068-73 |
| Wolfger H, et al. (2004) The yeast Pdr15p ATP-binding cassette (ABC) protein is a general stress response factor implicated in cellular detoxification. J Biol Chem 279(12):11593-9 |
| Stevens HC, et al. (2008) The Putative Aminophospholipid Translocases, DNF1 and DNF2, Are Not Required for 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-phosphatidylserine Flip across the Plasma Membrane of Saccharomyces cerevisiae. J Biol Chem 283(50):35060-9 |
| Rogers B, et al. (2001) The pleitropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3(2):207-14 |
| Mamnun YM, et al. (2004) Expression regulation of the yeast PDR5 ATP-binding cassette (ABC) transporter suggests a role in cellular detoxification during the exponential growth phase. FEBS Lett 559(1-3):111-7 |
| Jothi R, et al. (2009) Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture. Mol Syst Biol 5:294 |
| Mizoguchi H, et al. (2002) Different missense mutations in PDR1 and PDR3 genes from clotrimazole-resistant sake yeast are responsible for pleiotropic drug resistance and improved fermentative activity. J Biosci Bioeng 93(2):221-7 |
| Wawrzycka D, et al. (2010) Vmr 1p is a novel vacuolar multidrug resistance ABC transporter in Saccharomyces cerevisiae. FEMS Yeast Res 10(7):828-38 |
| Cernicka J, et al. (2007) Chemosensitisation of drug-resistant and drug-sensitive yeast cells to antifungals. Int J Antimicrob Agents 29(2):170-8 |
| Marin S, et al. (2002) Promoter-specific inhibition of transcription by daunorubicin in Saccharomyces cerevisiae. Biochem J 368(Pt 1):131-6 |
| Mahe Y, et al. (1996) The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. J Biol Chem 271(41):25167-72 |
| Onda M, et al. (2004) Analysis of gene network regulating yeast multidrug resistance by artificial activation of transcription factors: involvement of Pdr3 in salt tolerance. Gene 332():51-9 |
| Mutlu N, et al. (2014) Activation of the Pleiotropic Drug Resistance Pathway Can Promote Mitochondrial DNA Retention by Fusion-Defective Mitochondria in Saccharomyces cerevisiae. G3 (Bethesda) () |
| Nourani A, et al. (1997) Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domain. Mol Gen Genet 256(4):397-405 |
| Nishida N, et al. (2014) Activation of signaling pathways related to cell wall integrity and multidrug resistance by organic solvent in Saccharomyces cerevisiae. Curr Genet 60(3):149-62 |
| Kean LS, et al. (1997) Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. J Cell Biol 138(2):255-70 |
| Chinen T, et al. (2011) Construction of multidrug-sensitive yeast with high sporulation efficiency. Biosci Biotechnol Biochem 75(8):1588-93 |
| Venturi V, et al. (2012) The protein synthesis inhibitors mycalamides A and E have limited susceptibility toward the drug efflux network. J Biochem Mol Toxicol 26(3):94-100 |
| Balzi E, et al. (1987) The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem 262(35):16871-9 |
| Wehrschutz-Sigl E, et al. (2004) The transporters Pdr5p and Snq2p mediate diazaborine resistance and are under the control of the gain-of-function allele PDR1-12. Eur J Biochem 271(6):1145-52 |
| Cui Z, et al. (1998) Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Mol Microbiol 29(5):1307-15 |
| Souid AK, et al. (2006) ELM1 is required for multidrug resistance in Saccharomyces cerevisiae. Genetics 173(4):1919-37 |
| Devaux F, et al. (2002) Genome-wide studies on the nuclear PDR3-controlled response to mitochondrial dysfunction in yeast. FEBS Lett 515(1-3):25-8 |
| Decottignies A, et al. (1995) Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. J Biol Chem 270(30):18150-7 |
| Formenti LR and Kielland-Brandt MC (2011) Sensitivity to lovastatin of Saccharomyces cerevisiae strains deleted for pleiotropic drug resistance (PDR) genes. J Mol Microbiol Biotechnol 20(4):191-5 |
| Spincemaille P, et al. (2014) Sphingolipids and mitochondrial function in budding yeast. Biochim Biophys Acta 1840(10):3131-3137 |
| Hallstrom TC and Moye-Rowley WS (2000) Hyperactive forms of the Pdr1p transcription factor fail to respond to positive regulation by the hsp70 protein Pdr13p. Mol Microbiol 36(2):402-13 |
| Ogasawara Y, et al. (2008) New eremophilane sesquiterpenoid compounds, eremoxylarins a and B directly inhibit calcineurin in a manner independent of immunophilin. J Antibiot (Tokyo) 61(8):496-502 |
| Broco N, et al. (1999) FLR1 gene (ORF YBR008c) is required for benomyl and methotrexate resistance in Saccharomyces cerevisiae and its benomyl-induced expression is dependent on pdr3 transcriptional regulator. Yeast 15(15):1595-608 |
| Hanson PK and Nichols JW (2001) Energy-dependent flip of fluorescence-labeled phospholipids is regulated by nutrient starvation and transcription factors, PDR1 and PDR3. J Biol Chem 276(13):9861-7 |
| Dzugasova V, et al. (2010) Site-directed mutagenesis of Asp853 in Pdr3p transcriptional activator from Saccharomyces cerevisiae. Yeast 27(5):277-84 |
| Lis P, et al. (2012) Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae. J Bioenerg Biomembr 44(1):155-61 |
| Takacova M, et al. (2004) KNQ1, a Kluyveromyces lactis gene encoding a drug efflux permease. Curr Genet 45(1):1-8 |
| Matsufuji Y, et al. (2010) Transcription factor Stb5p is essential for acetaldehyde tolerance in Saccharomyces cerevisiae. J Basic Microbiol 50(5):494-8 |
| Vermitsky JP, et al. (2006) Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies. Mol Microbiol 61(3):704-22 |
| Ma M and Liu ZL (2010) Comparative transcriptome profiling analyses during the lag phase uncover YAP1, PDR1, PDR3, RPN4, and HSF1 as key regulatory genes in genomic adaptation to the lignocellulose derived inhibitor HMF for Saccharomyces cerevisiae. BMC G |
| Piper P, et al. (1998) The pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast. EMBO J 17(15):4257-65 |
| Shahi P, et al. (2010) Differential Roles of Transcriptional Mediator Subunits in Regulation of Multidrug Resistance Gene Expression in Saccharomyces cerevisiae. Mol Biol Cell 21(14):2469-82 |
| Edlind TD, et al. (2005) Promoter-dependent disruption of genes: simple, rapid, and specific PCR-based method with application to three different yeast. Curr Genet 48(2):117-25 |
| Ro DK, et al. (2008) Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid. BMC Biotechnol 883 |
| Balzi E and Goffeau A (1995) Yeast multidrug resistance: the PDR network. J Bioenerg Biomembr 27(1):71-6 |
| Taylor MP, et al. (2012) Understanding physiological responses to pre-treatment inhibitors in ethanologenic fermentations. Biotechnol J 7(9):1169-81 |
| MacPherson S, et al. (2006) A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol Mol Biol Rev 70(3):583-604 |
| Alenquer M, et al. (2006) Adaptive response to the antimalarial drug artesunate in yeast involves Pdr1p/Pdr3p-mediated transcriptional activation of the resistance determinants TPO1 and PDR5. FEMS Yeast Res 6(8):1130-9 |
| Kolaczkowska A, et al. (2008) Compensatory activation of the multidrug transporters Pdr5p, Snq2p, and Yor1p by Pdr1p in Saccharomyces cerevisiae. FEBS Lett 582(6):977-83 |
| Wolfger H, et al. (1997) The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. FEBS Lett 418(3):269-74 |
| Bussereau F, et al. (2006) The Kluyveromyces lactis repertoire of transcriptional regulators. FEMS Yeast Res 6(3):325-35 |
| DeRisi J, et al. (2000) Genome microarray analysis of transcriptional activation in multidrug resistance yeast mutants. FEBS Lett 470(2):156-60 |
| Hazelwood LA, et al. (2010) Involvement of Vacuolar Sequestration and Active Transport in Tolerance of Saccharomyces cerevisiae to Hop Iso-{alpha}-Acids. Appl Environ Microbiol 76(1):318-28 |
| Paul S, et al. (2011) Regulation of the CgPdr1 Transcription Factor from the Pathogen Candida glabrata. Eukaryot Cell 10(2):187-97 |
| Shen H, et al. (2007) Fcr1p Inhibits Development of Fluconazole Resistance in Candida albicans by Abolishing CDR1 Induction. Biol Pharm Bull 30(1):68-73 |
| Thakur JK, et al. (2008) A nuclear receptor-like pathway regulating multidrug resistance in fungi. Nature 452(7187):604-9 |
| Suzuki T and Iwahashi Y (2012) Comprehensive gene expression analysis of type B trichothecenes. J Agric Food Chem 60(37):9519-27 |
| Kozovska Z and Subik J (2003) Screening for effectors that modify multidrug resistance in yeast. Int J Antimicrob Agents 22(3):284-90 |
| Owsianik G, et al. (2002) Control of 26S proteasome expression by transcription factors regulating multidrug resistance in Saccharomyces cerevisiae. Mol Microbiol 43(5):1295-308 |
| Nikitin DV, et al. (2014) Chromosome translocation may lead to PRK1-dependent anticancer drug resistance in yeast via endocytic actin network deregulation. Eur J Cell Biol 93(4):145-56 |
| Akache B and Turcotte B (2002) New regulators of drug sensitivity in the family of yeast zinc cluster proteins. J Biol Chem 277(24):21254-60 |
| Sidorova M, et al. (2007) Loss-of-function pdr3 mutations convert the Pdr3p transcription activator to a protein suppressing multidrug resistance in Saccharomyces cerevisiae. FEMS Yeast Res 7(2):254-64 |
| Kolaczkowska A and Goffeau A (1999) Regulation of pleiotropic drug resistance in yeast. Drug Resist Updat 2(6):403-414 |
| Yoshida J, et al. (2013) Inhibition of Glycogen Synthase Kinase-3beta by Falcarindiol Isolated from Japanese Parsley (Oenanthe javanica). J Agric Food Chem 61(31):7515-7521 |
| Zhang X and Moye-Rowley WS (2001) Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase. J Biol Chem 276(51):47844-52 |
| Zhao XQ and Bai F (2012) Zinc and yeast stress tolerance: micronutrient plays a big role. J Biotechnol 158(4):176-83 |
| Larochelle M, et al. (2006) Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production. Mol Cell Biol 26(17):6690-701 |
| Chanklan R, et al. (2008) Identification of Saccharomyces cerevisiae Tub1 alpha-tubulin as a potential target for NKH-7, a cytotoxic 1-naphthol derivative compound. Biosci Biotechnol Biochem 72(4):1023-31 |
| Panwar SL and Moye-Rowley WS (2006) Long Chain Base Tolerance in Saccharomyces cerevisiae Is Induced by Retrograde Signals from the Mitochondria. J Biol Chem 281(10):6376-84 |
| Jones AW, et al. (2012) PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling. Mitochondrion 12(1):86-99 |
| Liu ZL (2011) Molecular mechanisms of yeast tolerance and in situ detoxification of lignocellulose hydrolysates. Appl Microbiol Biotechnol 90(3):809-25 |
| Teixeira MC and Sa-Correia I (2002) Saccharomyces cerevisiae resistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes. Biochem Biophys Res Commun 292(2):530-7 |
| Wang Y, et al. (2009) Predicting eukaryotic transcriptional cooperativity by Bayesian network integration of genome-wide data. Nucleic Acids Res 37(18):5943-58 |
| Schuller C, et al. (2007) Membrane-active Compounds Activate the Transcription Factors Pdr1 and Pdr3 Connecting Pleiotropic Drug Resistance and Membrane Lipid Homeostasis in Saccharomyces cerevisiae. Mol Biol Cell 18(12):4932-44 |
| Gao C, et al. (2004) On the mechanism of constitutive Pdr1 activator-mediated PDR5 transcription in Saccharomyces cerevisiae: evidence for enhanced recruitment of coactivators and altered nucleosome structures. J Biol Chem 279(41):42677-86 |
| Mira NP, et al. (2010) Adaptive Response and Tolerance to Weak Acids in Saccharomyces cerevisiae: A Genome-Wide View. OMICS 14(5):525-40 |
| Katzmann DJ, et al. (1994) Transcriptional control of the yeast PDR5 gene by the PDR3 gene product. Mol Cell Biol 14(7):4653-61 |
| Decottignies A, et al. (1994) Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast. J Biol Chem 269(17):12797-803 |
| Wendler F, et al. (1997) Diazaborine resistance in the yeast Saccharomyces cerevisiae reveals a link between YAP1 and the pleiotropic drug resistance genes PDR1 and PDR3. J Biol Chem 272(43):27091-8 |