| Zhou X and O'Shea EK (2011) Integrated Approaches Reveal Determinants of Genome-wide Binding and Function of the Transcription Factor Pho4. Mol Cell 42(6):826-36 |
| Zheng J, et al. (2010) Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol 6():420 |
| Terrell AR, et al. (2002) Reconstitution of nucleosome positioning, remodeling, histone acetylation, and transcriptional activation on the PHO5 promoter. J Biol Chem 277(34):31038-47 |
| Cai L and Tu BP (2012) Driving the cell cycle through metabolism. Annu Rev Cell Dev Biol 28():59-87 |
| Sengstag C and Hinnen A (1987) The sequence of the Saccharomyces cerevisiae gene PHO2 codes for a regulatory protein with unusual aminoacid composition. Nucleic Acids Res 15(1):233-46 |
| Barbaric S, et al. (1998) Cooperative Pho2-Pho4 interactions at the PHO5 promoter are critical for binding of Pho4 to UASp1 and for efficient transactivation by Pho4 at UASp2. Mol Cell Biol 18(5):2629-39 |
| Mouillon JM and Persson BL (2006) New aspects on phosphate sensing and signalling in Saccharomyces cerevisiae. FEMS Yeast Res 6(2):171-6 |
| Venter U, et al. (1994) A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter. EMBO J 13(20):4848-55 |
| Griesenbeck J, et al. (2003) Affinity purification of specific chromatin segments from chromosomal loci in yeast. Mol Cell Biol 23(24):9275-82 |
| Zhao Y, et al. (2008) Development of a Novel Oligonucleotide Array-Based Transcription Factor Assay Platform for Genome-Wide Active Transcription Factor Profiling in Saccharomyces cerevisiae. J Proteome Res 7(3):1315-1325 |
| Kerwin CL and Wykoff DD (2009) Candida glabrata PHO4 Is Necessary and Sufficient for Pho2-Independent Transcription of Phosphate Starvation Genes. Genetics 182(2):471-9 |
| Xia ZX and Ao SZ (1999) PHO4 and PHO2 Protein Interact with Upstream Sequence of PHO81 Gene. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 31(2):191-196 |
| Auesukaree C, et al. (2005) Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae. J Biol Chem 280(26):25127-33 |
| Ertel F, et al. (2010) In Vitro Reconstitution of PHO5 Promoter Chromatin Remodeling Points to a Role for Activator-Nucleosome Competition In Vivo. Mol Cell Biol 30(16):4060-76 |
| Creasy CL, et al. (1996) Negative transcriptional regulation of PH081 expression in Saccharomyces cerevisiae. Gene 168(1):23-9 |
| Vogel K, et al. (1989) The two positively acting regulatory proteins PHO2 and PHO4 physically interact with PHO5 upstream activation regions. Mol Cell Biol 9(5):2050-7 |
| Liu C, et al. (2000) Regulation of the yeast transcriptional factor PHO2 activity by phosphorylation. J Biol Chem 275(41):31972-8 |
| Secco D, et al. (2012) Phosphate homeostasis in the yeast Saccharomyces cerevisiae, the key role of the SPX domain-containing proteins. FEBS Lett 586(4):289-95 |
| Xia ZX and Ao SZ (1999) Functional Analysis of the Upstream Sequence of PHO81 Gene of Saccharomyces cerevisiae. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 31(1):83-89 |
| Sambuk EV, et al. (2011) Acid phosphatases of budding yeast as a model of choice for transcription regulation research. Enzyme Res 2011():356093 |
| Haswell ES and O'Shea EK (1999) An in vitro system recapitulates chromatin remodeling at the PHO5 promoter. Mol Cell Biol 19(4):2817-27 |
| Tsang F, et al. (2015) Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae. J Biol Chem 290(20):12753-64 |
| Lee M, et al. (2000) Regulation of the Pcl7-Pho85 cyclin-cdk complex by Pho81. Mol Microbiol 38(2):411-22 |
| Serrano R, et al. (2002) The transcriptional response to alkaline pH in Saccharomyces cerevisiae: evidence for calcium-mediated signalling. Mol Microbiol 46(5):1319-33 |
| Biddick R and Young ET (2009) The disorderly study of ordered recruitment. Yeast 26(4):205-20 |
| Magbanua JP, et al. (1997) The homeodomain protein Pho2p binds at an A/T-rich segment flanking the binding site of the basic-helix-loop-helix protein Pho4p in the yeast PHO promoters. Yeast 13(14):1299-308 |
| Bhoite LT, et al. (2002) Mutations in the pho2 (bas2) transcription factor that differentially affect activation with its partner proteins bas1, pho4, and swi5. J Biol Chem 277(40):37612-8 |
| Toh-e A, et al. (1976) A gene controlling the synthesis of non specific alkaline phosphatase in Saccharomyces cerevisiae. Biochim Biophys Acta 428(1):182-92 |
| Achcar F, et al. (2011) A Boolean probabilistic model of metabolic adaptation to oxygen in relation to iron homeostasis and oxidative stress. BMC Syst Biol 5(1):51 |
| Samyn DR and Persson BL (2016) Inorganic Phosphate and Sulfate Transport in S. cerevisiae. Adv Exp Med Biol 892():253-69 |
| Oshima Y (1997) The phosphatase system in Saccharomyces cerevisiae. Genes Genet Syst 72(6):323-34 |
| Beskow A and Wright AP (2006) Comparative analysis of regulatory transcription factors in Schizosaccharomyces pombe and budding yeasts. Yeast 23(13):929-35 |
| Komeili A and O'Shea EK (1999) Roles of phosphorylation sites in regulating activity of the transcription factor Pho4. Science 284(5416):977-80 |
| To-E A, et al. (1973) Isolation and characterization of acid phosphatase mutants in Saccharomyces cerevisiae. J Bacteriol 113(2):727-38 |
| Tomar P and Sinha H (2014) Conservation of PHO pathway in ascomycetes and the role of Pho84. J Biosci 39(3):525-36 |
| Yadav KK, et al. (2015) Responses to phosphate deprivation in yeast cells. Curr Genet () |
| Ferminan E and Dominguez A (1997) The KIPHO5 gene encoding a repressible acid phosphatase in the yeast Kluyveromyces lactis: cloning, sequencing and transcriptional analysis of the gene, and purification and properties of the enzyme. Microbiology 143 ( Pt |
| Rajkumar AS, et al. (2013) Mapping the fine structure of a eukaryotic promoter input-output function. Nat Genet 45(10):1207-15 |
| Pinson B, et al. (2009) Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways. Genes Dev 23(12):1399-407 |
| Sengstag C and Hinnen A (1988) A 28-bp segment of the Saccharomyces cerevisiae PHO5 upstream activator sequence confers phosphate control to the CYC1-lacZ gene fusion. Gene 67(2):223-8 |
| Kaffman A, et al. (1994) Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. Science 263(5150):1153-6 |
| Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31 |
| Lu CC, et al. (2008) Extracting transcription factor binding sites from unaligned gene sequences with statistical models. BMC Bioinformatics 9 Suppl 12:S7 |
| Ljungdahl PO and Daignan-Fornier B (2012) Regulation of Amino Acid, Nucleotide, and Phosphate Metabolism in Saccharomyces cerevisiae. Genetics 190(3):885-929 |
| Adkins MW and Tyler JK (2006) Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions. Mol Cell 21(3):405-16 |
| Hirst K, et al. (1994) The transcription factor, the Cdk, its cyclin and their regulator: directing the transcriptional response to a nutritional signal. EMBO J 13(22):5410-20 |
| Lu SP and Lin SJ (2011) Phosphate-responsive Signaling Pathway Is a Novel Component of NAD+ Metabolism in Saccharomyces cerevisiae. J Biol Chem 286(16):14271-81 |
| Yoshida K, et al. (1989) Function of the PHO regulatory genes for repressible acid phosphatase synthesis in Saccharomyces cerevisiae. Mol Gen Genet 217(1):40-6 |
| Neef DW and Kladde MP (2003) Polyphosphate loss promotes SNF/SWI- and Gcn5-dependent mitotic induction of PHO5. Mol Cell Biol 23(11):3788-97 |
| Shao D, et al. (1996) Interaction of Saccharomyces cerevisiae Pho2 with Pho4 increases the accessibility of the activation domain of Pho4. Mol Gen Genet 251(3):358-64 |
| Gardocki ME, et al. (2005) Genomic analysis of PIS1 gene expression. Eukaryot Cell 4(3):604-14 |
| Gordan R, et al. (2011) Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol 12(12):R125 |
| Nishimura K, et al. (1999) Transcription of some PHO genes in Saccharomyces cerevisiae is regulated by spt7p. Yeast 15(16):1711-7 |
| Lai WK and Buck MJ (2013) An integrative approach to understanding the combinatorial histone code at functional elements. Bioinformatics 29(18):2231-7 |
| Joshi A, et al. (2010) Characterizing regulatory path motifs in integrated networks using perturbational data. Genome Biol 11(3):R32 |
| Tu WY, et al. (2011) Rpl12p affects the transcription of the PHO pathway high-affinity inorganic phosphate transporters and repressible phosphatases. Yeast 28(6):481-93 |
| Magbanua JP, et al. (1997) The transcriptional activators of the PHO regulon, Pho4p and Pho2p, interact directly with each other and with components of the basal transcription machinery in Saccharomyces cerevisiae. J Biochem 121(6):1182-9 |
| Nicolson TA, et al. (1995) A truncated form of the Pho80 cyclin redirects the Pho85 kinase to disrupt vacuole inheritance in S. cerevisiae. J Cell Biol 130(4):835-45 |
| Sung MK and Huh WK (2007) Bimolecular fluorescence complementation analysis system for in vivo detection of protein-protein interaction in Saccharomyces cerevisiae. Yeast 24(9):767-75 |
| Sambade M, et al. (2005) A genomic screen for yeast vacuolar membrane ATPase mutants. Genetics 170(4):1539-51 |
| Nourani A, et al. (2004) Recruitment of the NuA4 complex poises the PHO5 promoter for chromatin remodeling and activation. EMBO J 23(13):2597-607 |
| Wang SS, et al. (2011) Histone H3 lysine 4 hypermethylation prevents aberrant nucleosome remodeling at the PHO5 promoter. Mol Cell Biol 31(15):3171-81 |
| Barbaric S, et al. (1996) The homeodomain protein Pho2 and the basic-helix-loop-helix protein Pho4 bind DNA cooperatively at the yeast PHO5 promoter. Nucleic Acids Res 24(22):4479-86 |
| Holbein S, et al. (2008) Cordycepin-hypersensitive growth links elevated polyphosphate levels to inhibition of poly(A) polymerase in Saccharomyces cerevisiae. Nucleic Acids Res 36(2):353-63 |
| Siddharthan R, et al. (2005) PhyloGibbs: a Gibbs sampling motif finder that incorporates phylogeny. PLoS Comput Biol 1(7):e67 |
| Adkins MW, et al. (2007) Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators. Mol Cell Biol 27(18):6372-82 |
| Yoshida K, et al. (1989) Mode of expression of the positive regulatory genes PHO2 and PHO4 of the phosphatase regulon in Saccharomyces cerevisiae. Mol Gen Genet 217(1):31-9 |
| Lemire JM, et al. (1985) Regulation of repressible acid phosphatase gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 5(8):2131-41 |
| O'Connell KF and Baker RE (1992) Possible cross-regulation of phosphate and sulfate metabolism in Saccharomyces cerevisiae. Genetics 132(1):63-73 |
| Springer M, et al. (2003) Partially phosphorylated Pho4 activates transcription of a subset of phosphate-responsive genes. PLoS Biol 1(2):E28 |
| Morozov AV and Siggia ED (2007) Connecting protein structure with predictions of regulatory sites. Proc Natl Acad Sci U S A 104(17):7068-73 |
| Serrano R, et al. (2004) Copper and iron are the limiting factors for growth of the yeast Saccharomyces cerevisiae in an alkaline environment. J Biol Chem 279(19):19698-704 |
| Fascher KD, et al. (1990) Role of trans-activating proteins in the generation of active chromatin at the PHO5 promoter in S. cerevisiae. EMBO J 9(8):2523-8 |
| Pinson B, et al. (2004) Low affinity orthophosphate carriers regulate PHO gene expression independently of internal orthophosphate concentration in Saccharomyces cerevisiae. J Biol Chem 279(34):35273-80 |
| Wongwisansri S and Laybourn PJ (2005) Disruption of histone deacetylase gene RPD3 accelerates PHO5 activation kinetics through inappropriate Pho84p recycling. Eukaryot Cell 4(8):1387-95 |
| Toh-e A, et al. (1983) An insertion mutation associated with constitutive expression of repressible acid phosphatase in Saccharomyces cerevisiae. Mol Gen Genet 191(3):339-46 |
| Brown CR, et al. (2013) Linking stochastic fluctuations in chromatin structure and gene expression. PLoS Biol 11(8):e1001621 |
| Berben G, et al. (1988) Studies on the structure, expression and function of the yeast regulatory gene PHO2. Gene 66(2):307-12 |
| Dos Santos SC and Sa-Correia I (2011) A genome-wide screen identifies yeast genes required for protection against or enhanced cytotoxicity of the antimalarial drug quinine. Mol Genet Genomics 286(5-6):333-46 |
| Dos Santos SC, et al. (2009) Transcriptomic profiling of the Saccharomyces cerevisiae response to quinine reveals a glucose limitation response attributable to drug-induced inhibition of glucose uptake. Antimicrob Agents Chemother 53(12):5213-23 |
| Brown SJ, et al. (2008) Evolution of the holozoan ribosome biogenesis regulon. BMC Genomics 9:442 |
| Sung MK and Huh WK (2010) In vivo quantification of protein-protein interactions in Saccharomyces cerevisiae using bimolecular fluorescence complementation assay. J Microbiol Methods 83(2):194-201 |
| Rando OJ and Winston F (2012) Chromatin and transcription in yeast. Genetics 190(2):351-87 |
| Mao C, et al. (2011) Occlusion of regulatory sequences by promoter nucleosomes in vivo. PLoS One 6(3):e17521 |
| Toh-e A (1980) Genetic Mapping of the pho2, PHO82-pho4 and pho85 Loci of Yeast. Genetics 94(4):929-932 |
| Wang Y, et al. (2009) Predicting eukaryotic transcriptional cooperativity by Bayesian network integration of genome-wide data. Nucleic Acids Res 37(18):5943-58 |
| Almaguer C, et al. (2004) Glycerophosphoinositol, a novel phosphate source whose transport is regulated by multiple factors in Saccharomyces cerevisiae. J Biol Chem 279(30):31937-42 |
| Nishizawa M, et al. (2001) Pho85 kinase, a yeast cyclin-dependent kinase, regulates the expression of UGP1 encoding UDP-glucose pyrophosphorylase. Yeast 18(3):239-49 |
| Arino J (2010) Integrative Responses to High pH Stress in S. cerevisiae. OMICS 14(5):517-23 |
| Lenburg ME and O'Shea EK (1996) Signaling phosphate starvation. Trends Biochem Sci 21(10):383-7 |