The 98 papers which experimentally study the biological roles of both TFs of the PCTFP (Rtg3-Rtg1)
Ruetenik A and Barrientos A (2015) Dietary restriction, mitochondrial function and aging: from yeast to humans. Biochim Biophys Acta 1847(11):1434-47
Martinez Pastor M, et al. (2009) Mitochondrial function is an inducible determinant of osmotic stress adaptation in yeast. J Biol Chem 284(44):30307-17
Kaeberlein M, et al. (2007) Recent developments in yeast aging. PLoS Genet 3(5):e84
Sekito T, et al. (2000) Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol Biol Cell 11(6):2103-15
Barreto L, et al. (2012) The short-term response of yeast to potassium starvation. Environ Microbiol 14(11):3026-42
Neklesa TK and Davis RW (2009) A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex. PLoS Genet 5(6):e1000515
Benschop JJ, et al. (2010) A Consensus of Core Protein Complex Compositions for Saccharomyces cerevisiae. Mol Cell 38(6):916-928
Berry DB, et al. (2011) Multiple means to the same end: the genetic basis of acquired stress resistance in yeast. PLoS Genet 7(11):e1002353
Pan Z, et al. (2008) Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol. BMC Med Genomics 1:7
Zhao Y, et al. (2008) Development of a Novel Oligonucleotide Array-Based Transcription Factor Assay Platform for Genome-Wide Active Transcription Factor Profiling in Saccharomyces cerevisiae. J Proteome Res 7(3):1315-1325
Liu Z and Butow RA (1999) A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function. Mol Cell Biol 19(10):6720-8
Jazwinski SM (2014) The retrograde response: a conserved compensatory reaction to damage from within and from without. Prog Mol Biol Transl Sci 127():133-54
Liu Z, et al. (2003) Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Mol Cell 12(2):401-11
Babbitt GA (2010) Relaxed selection against accidental binding of transcription factors with conserved chromatin contexts. Gene 466(1-2):43-8
Dalal CK, et al. (2014) Pulsatile dynamics in the yeast proteome. Curr Biol 24(18):2189-94
de Virgilio C (2012) The essence of yeast quiescence. FEMS Microbiol Rev 36(2):306-39
Hartman JL 4th (2007) Buffering of deoxyribonucleotide pool homeostasis by threonine metabolism. Proc Natl Acad Sci U S A 104(28):11700-5
Tate JJ, et al. (2002) Mks1p is required for negative regulation of retrograde gene expression in Saccharomyces cerevisiae but does not affect nitrogen catabolite repression-sensitive gene expression. J Biol Chem 277(23):20477-82
Chen L and Lopes JM (2010) Multiple bHLH proteins regulate CIT2 expression in Saccharomyces cerevisiae. Yeast 27(6):345-59
Jazwinski SM (1999) Molecular mechanisms of yeast longevity. Trends Microbiol 7(6):247-52
Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43(3):139-60
Arlia-Ciommo A, et al. (2014) Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan. Cell Cycle 13(21):3336-49
Chavel CA, et al. (2010) Multiple signals converge on a differentiation MAPK pathway. PLoS Genet 6(3):e1000883
Giannattasio S, et al. (2013) Molecular mechanisms of Saccharomyces cerevisiae stress adaptation and programmed cell death in response to acetic acid. Front Microbiol 4():33
Stewart-Ornstein J, et al. (2012) Cellular Noise Regulons Underlie Fluctuations in Saccharomyces cerevisiae. Mol Cell 45(4):483-93
Del Giudice L, et al. (2005) Interaction between yeast mitochondrial and nuclear genomes: null alleles of RTG genes affect resistance to the alkaloid lycorine in rho0 petites of Saccharomyces cerevisiae. Gene 354():9-14
Towpik J (2005) Regulation of mitochondrial translation in yeast. Cell Mol Biol Lett 10(4):571-94
Beskow A and Wright AP (2006) Comparative analysis of regulatory transcription factors in Schizosaccharomyces pombe and budding yeasts. Yeast 23(13):929-35
Hashim Z, et al. (2014) Metabolic profiling of retrograde pathway transcription factors rtg1 and rtg3 knockout yeast. Metabolites 4(3):580-98
Dilova I, et al. (2007) Calorie restriction and the nutrient sensing signaling pathways. Cell Mol Life Sci 64(6):752-67
Jazwinski SM (2000) Metabolic mechanisms of yeast ageing. Exp Gerontol 35(6-7):671-6
Kaniak-Golik A and Skoneczna A (2015) Mitochondria-nucleus network for genome stability. Free Radic Biol Med 82():73-104
de Virgilio C and Loewith R (2006) Cell growth control: little eukaryotes make big contributions. Oncogene 25(48):6392-415
Theis JF, et al. (2010) The DNA Damage Response Pathway Contributes to the Stability of Chromosome III Derivatives Lacking Efficient Replicators. PLoS Genet 6(12):e1001227
Nishida-Aoki N, et al. (2015) Activation of the mitochondrial signaling pathway in response to organic solvent stress in yeast. Curr Genet 61(2):153-164
Jazwinski SM and Kriete A (2012) The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction. Front Physiol 3():139
Jazwinski SM (2012) The Retrograde ResponseRetrograde Response and Other Pathways of Interorganelle CommunicationInterorganelle Communication in Yeast Replicative Aging. Subcell Biochem 57():79-100
Rohde JR, et al. (2008) Nutritional control via Tor signaling in Saccharomyces cerevisiae. Curr Opin Microbiol 11(2):153-60
Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31
Breitenbach M, et al. (2012) The role of mitochondria in the aging processes of yeast. Subcell Biochem 57():55-78
van Werven FJ and Amon A (2011) Regulation of entry into gametogenesis. Philos Trans R Soc Lond B Biol Sci 366(1584):3521-31
May AI, et al. (2012) The many faces of mitochondrial autophagy: making sense of contrasting observations in recent research. Int J Cell Biol 2012():431684
Spincemaille P, et al. (2014) Sphingolipids and mitochondrial function in budding yeast. Biochim Biophys Acta 1840(10):3131-3137
Hill S and Van Remmen H (2014) Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging. Redox Biol 2():936-944
Khoury CM, et al. (2008) A TSC22-like motif defines a novel antiapoptotic protein family. FEMS Yeast Res 8(4):540-63
Osiewacz HD and Scheckhuber CQ (2006) Impact of ROS on ageing of two fungal model systems: Saccharomyces cerevisiae and Podospora anserina. Free Radic Res 40(12):1350-8
Guaragnella N, et al. (2014) The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2. FEMS Yeast Res 14(1):2-16
Robinson KA, et al. (2000) A network of yeast basic helix-loop-helix interactions. Nucleic Acids Res 28(22):4460-6
Chen EJ and Kaiser CA (2003) LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway. J Cell Biol 161(2):333-47
Butow RA and Avadhani NG (2004) Mitochondrial signaling: the retrograde response. Mol Cell 14(1):1-15
Starovoytova AN, et al. (2013) Mitochondrial signaling in Saccharomyces cerevisiae pseudohyphae formation induced by butanol. FEMS Yeast Res 13(4):367-74
Yu T and Li KC (2005) Inference of transcriptional regulatory network by two-stage constrained space factor analysis. Bioinformatics 21(21):4033-8
Zasheva D and Alexandar I (2005) Protein release in a Saccharomyces cerevisiae mutant does not depend on mitochondrial genome integrity and function. Microbiol Res 160(3):219-23
Ruiz-Roig C, et al. (2012) The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms. Mol Biol Cell 23(21):4286-96
Chelstowska A, et al. (1999) Signalling between mitochondria and the nucleus regulates the expression of a new D-lactate dehydrogenase activity in yeast. Yeast 15(13):1377-91
Shetty A and Lopes JM (2010) Derepression of INO1 Transcription Requires Cooperation between the Ino2p-Ino4p Heterodimer and Cbf1p and Recruitment of the ISW2 Chromatin-Remodeling Complex. Eukaryot Cell 9(12):1845-55
Madeira JB, et al. (2015) TORC1 Inhibition Induces Lipid Droplet Replenishment in Yeast. Mol Cell Biol 35(4):737-46
Jia Y, et al. (1997) A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol 17(3):1110-7
Murray DB, et al. (2011) Redox regulation in respiring Saccharomyces cerevisiae. Biochim Biophys Acta 1810(10):945-58
Crespo JL, et al. (2002) The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci U S A 99(10):6784-9
Chen M and Lopes JM (2007) Multiple Basic Helix-Loop-Helix Proteins Regulate Expression of the ENO1 Gene of Saccharomyces cerevisiae. Eukaryot Cell 6(5):786-96
Chang YW, et al. (2008) Roles of cis- and trans-changes in the regulatory evolution of genes in the gluconeogenic pathway in yeast. Mol Biol Evol 25(9):1863-75
Jazwinski SM (2013) The retrograde response: when mitochondrial quality control is not enough. Biochim Biophys Acta 1833(2):400-9
Jothi R, et al. (2009) Genomic analysis reveals a tight link between transcription factor dynamics and regulatory network architecture. Mol Syst Biol 5:294
Peters TW, et al. (2015) Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae. G3 (Bethesda) 6(1):161-70
Rothermel BA, et al. (1997) Rtg3p, a basic helix-loop-helix/leucine zipper protein that functions in mitochondrial-induced changes in gene expression, contains independent activation domains. J Biol Chem 272(32):19801-7
Srinivasan V, et al. (2010) Comparing the yeast retrograde response and NF-kappaB stress responses: implications for aging. Aging Cell 9(6):933-41
Komeili A, et al. (2000) Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J Cell Biol 151(4):863-78
Powers T, et al. (2004) Yeast TOR signaling: a mechanism for metabolic regulation. Curr Top Microbiol Immunol 279():39-51
Jazwinski SM (2015) Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging. Ageing Res Rev 23(Pt A):67-74
Dilova I, et al. (2004) Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes. J Biol Chem 279(45):46527-35
Wang RS, et al. (2007) Inferring transcriptional regulatory networks from high-throughput data. Bioinformatics 23(22):3056-3064
Chan K and Roth MB (2008) Anoxia-induced suspended animation in budding yeast as an experimental paradigm for studying oxygen-regulated gene expression. Eukaryot Cell 7(10):1795-808
Morozov AV and Siggia ED (2007) Connecting protein structure with predictions of regulatory sites. Proc Natl Acad Sci U S A 104(17):7068-73
Beach A, et al. (2015) Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome. Cell Cycle 14(11):1643-56
Hagerman RA, et al. (2002) The regulation of COQ5 gene expression by energy source. Free Radic Res 36(4):485-90
Farooq MA, et al. (2013) Mitochondrial DNA instability in cells lacking aconitase correlates with iron citrate toxicity. Oxid Med Cell Longev 2013():493536
Sekito T, et al. (2002) RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3]. Mol Biol Cell 13(3):795-804
Chen XJ, et al. (2007) Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA. Proc Natl Acad Sci U S A 104(34):13738-43
Hagerman RA and Willis RA (2002) The yeast gene COQ5 is differentially regulated by Mig1p, Rtg3p and Hap2p. Biochim Biophys Acta 1578(1-3):51-8
Massari ME and Murre C (2000) Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 20(2):429-40
Liu Z, et al. (2001) RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J 20(24):7209-19
Bussereau F, et al. (2006) The Kluyveromyces lactis repertoire of transcriptional regulators. FEMS Yeast Res 6(3):325-35
Robinson KA and Lopes JM (2000) SURVEY AND SUMMARY: Saccharomyces cerevisiae basic helix-loop-helix proteins regulate diverse biological processes. Nucleic Acids Res 28(7):1499-505
Broach JR (2012) Nutritional control of growth and development in yeast. Genetics 192(1):73-105
Dilova I, et al. (2002) Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae. Curr Biol 12(5):389-95
Conrad M, et al. (2014) Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae. FEMS Microbiol Rev 38(2):254-99
Fendt SM, et al. (2010) Unraveling condition-dependent networks of transcription factors that control metabolic pathway activity in yeast. Mol Syst Biol 6():432
Denoth A, et al. (2014) Budding yeast as a model organism to study the effects of age. FEMS Microbiol Rev 38(2):300-25
Engelberg D, et al. (2014) Transmembrane signaling in Saccharomyces cerevisiae as a model for signaling in metazoans: state of the art after 25 years. Cell Signal 26(12):2865-78
Dilova I and Powers T (2006) Accounting for strain-specific differences during RTG target gene regulation in Saccharomyces cerevisiae. FEMS Yeast Res 6(1):112-9
Jazwinski SM (2000) Metabolic control and ageing. Trends Genet 16(11):506-11
Alberghina L, et al. (2011) Cell growth and cell cycle in Saccharomyces cerevisiae: basic regulatory design and protein-protein interaction network. Biotechnol Adv 30(1):52-72
Zdralevic M, et al. (2012) Yeast as a tool to study signaling pathways in mitochondrial stress response and cytoprotection. ScientificWorldJournal 2012():912147
Jones AW, et al. (2012) PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling. Mitochondrion 12(1):86-99
Vujcic M, et al. (2007) Genetic Determinants of Mitochondrial Response to Arsenic in Yeast Saccharomyces cerevisiae. Cancer Res 67(20):9740-9
Epstein CB, et al. (2001) Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell 12(2):297-308
Pierce MM, et al. (2001) A novel Rtg2p activity regulates nitrogen catabolism in yeast. Proc Natl Acad Sci U S A 98(23):13213-8