The 64 papers which experimentally study the biological roles of both TFs of the PCTFP (Ume6-Sin3)
Grigat M, et al. (2012) Multiple histone deacetylases are recruited by corepressor Sin3 and contribute to gene repression mediated by Opi1 regulator of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 287(6):461-72
Hancock LC, et al. (2006) Genomic analysis of the Opi- phenotype. Genetics 173(2):621-34
Piekarska I, et al. (2010) Regulation of sporulation in the yeast Saccharomyces cerevisiae. Acta Biochim Pol 57(3):241-50
Rundlett SE, et al. (1998) Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature 392(6678):831-5
Kassir Y, et al. (2003) Transcriptional regulation of meiosis in budding yeast. Int Rev Cytol 224():111-71
Morano KA, et al. (2012) The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics 190(4):1157-95
Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31
McCauley BS and Dang W (2014) Histone methylation and aging: lessons learned from model systems. Biochim Biophys Acta 1839(12):1454-62
Henry SA, et al. (2014) The response to inositol: Regulation of glycerolipid metabolism and stress response signaling in yeast. Chem Phys Lipids 180C():23-43
Carrozza MJ, et al. (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92
On T, et al. (2010) The evolutionary landscape of the chromatin modification machinery reveals lineage specific gains, expansions, and losses. Proteins 78(9):2075-89
Ruotolo R, et al. (2008) Membrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast. Genome Biol 9(4):R67
Kadosh D and Struhl K (1997) Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89(3):365-71
Schroder M, et al. (2004) The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. EMBO J 23(11):2281-92
Jani NM and Lopes JM (2008) Transcription regulation of the Saccharomyces cerevisiae PIS1 gene by inositol and the pleiotropic regulator, Ume6p. Mol Microbiol 70(6):1529-39
Ottosson LG, et al. (2010) Sulfate Assimilation Mediates Tellurite Reduction and Toxicity in Saccharomyces cerevisiae. Eukaryot Cell 9(10):1635-1647
Gilmore JM, et al. (2012) Characterization of a highly conserved histone related protein, Ydl156w, and its functional associations using quantitative proteomic analyses. Mol Cell Proteomics 11(4):M111.011544
Strich R, et al. (1989) Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Proc Natl Acad Sci U S A 86(24):10018-22
Lardenois A, et al. (2015) The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development. Nucleic Acids Res 43(1):115-28
Backues SK, et al. (2012) The Ume6-Sin3-Rpd3 complex regulates ATG8 transcription to control autophagosome size. Autophagy 8(12):1835-6
Kadosh D and Struhl K (1998) Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo. Mol Cell Biol 18(9):5121-7
Chen SH, et al. (2010) A proteome-wide analysis of kinase-substrate network in the DNA damage response. J Biol Chem 285(17):12803-12
Bernstein BE, et al. (2000) Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A 97(25):13708-13
Singh J (2014) Role of DNA replication in establishment and propagation of epigenetic states of chromatin. Semin Cell Dev Biol 30C():131-143
Bowdish KS and Mitchell AP (1993) Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae. Mol Cell Biol 13(4):2172-81
Zhou J, et al. (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res 37(11):3699-713
Bartholomew CR, et al. (2012) Ume6 transcription factor is part of a signaling cascade that regulates autophagy. Proc Natl Acad Sci U S A 109(28):11206-10
Lahue R and Frizzell A (2012) Histone deacetylase complexes as caretakers of genome stability. Epigenetics 7(8):806-10
Sardiu ME, et al. (2009) Determining protein complex connectivity using a probabilistic deletion network derived from quantitative proteomics. PLoS One 4(10):e7310
Shevchenko A, et al. (2008) Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment. Genome Biol 9(11):R167
Kaadige MR and Lopes JM (2003) Opi1p, Ume6p and Sin3p control expression from the promoter of the INO2 regulatory gene via a novel regulatory cascade. Mol Microbiol 48(3):823-32
Milliman EJ, et al. (2012) Recruitment of rpd3 to the telomere depends on the protein arginine methyltransferase hmt1. PLoS One 7(8):e44656
Washburn BK and Esposito RE (2001) Identification of the Sin3-binding site in Ume6 defines a two-step process for conversion of Ume6 from a transcriptional repressor to an activator in yeast. Mol Cell Biol 21(6):2057-69
Mallory MJ, et al. (2010) The Sin3p PAH Domains Provide Separate Functions Repressing Meiotic Gene Transcription in Saccharomyces cerevisiae. Eukaryot Cell 9(12):1835-44
Winter E (2012) The Sum1/Ndt80 Transcriptional Switch and Commitment to Meiosis in Saccharomyces cerevisiae. Microbiol Mol Biol Rev 76(1):1-15
Kurdistani SK, et al. (2002) Genome-wide binding map of the histone deacetylase Rpd3 in yeast. Nat Genet 31(3):248-54
Pnueli L, et al. (2004) Glucose and nitrogen regulate the switch from histone deacetylation to acetylation for expression of early meiosis-specific genes in budding yeast. Mol Cell Biol 24(12):5197-208
Irniger S (2011) The Ime2 protein kinase family in fungi: more duties than just meiosis. Mol Microbiol 80(1):1-13
Ruiz-Roig C, et al. (2010) The Rpd3L HDAC complex is essential for the heat stress response in yeast. Mol Microbiol 76(4):1049-62
Tong AH, et al. (2004) Global mapping of the yeast genetic interaction network. Science 303(5659):808-13
Shima J, et al. (2008) Possible roles of vacuolar H(+)-ATPase and mitochondrial function in tolerance to air-drying stress revealed by genome-wide screening of Saccharomyces cerevisiae deletion strains. Yeast 25(3):179-90
Messenguy F, et al. (2000) In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex. J Bacteriol 182(11):3158-6
Bruckner S and Mosch HU (2012) Choosing the right lifestyle: adhesion and development in Saccharomyces cerevisiae. FEMS Microbiol Rev 36(1):25-58
Shimizu M, et al. (2003) Yeast Ume6p repressor permits activator binding but restricts TBP binding at the HOP1 promoter. Nucleic Acids Res 31(12):3033-7
Sikorski TW, et al. (2012) Proteomic analysis demonstrates activator- and chromatin-specific recruitment to promoters. J Biol Chem 287(42):35397-408
Narlikar GJ, et al. (2002) Cooperation between complexes that regulate chromatin structure and transcription. Cell 108(4):475-87
Nagy PD (2008) Yeast as a model host to explore plant virus-host interactions. Annu Rev Phytopathol 46:217-42
Aihara M, et al. (2014) Tor and the Sin3-Rpd3 complex regulate expression of the mitophagy receptor protein Atg32 in yeast. J Cell Sci 127(Pt 14):3184-96
Goldmark JP, et al. (2000) The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p. Cell 103(3):423-33
Knott SR, et al. (2009) Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae. Genes Dev 23(9):1077-90
Yukawa M, et al. (2009) The Rpd3/HDAC complex is present at the URS1 cis-element with hyperacetylated histone H3. Biosci Biotechnol Biochem 73(2):378-84
Becker E, et al. (2015) Integrated RNA- and protein profiling of fermentation and respiration in diploid budding yeast provides insight into nutrient control of cell growth and development. J Proteomics 119():30-44
Luscombe NM, et al. (2004) Genomic analysis of regulatory network dynamics reveals large topological changes. Nature 431(7006):308-12
Borecka-Melkusova S, et al. (2008) RPD3 and ROM2 are required for multidrug resistance in Saccharomyces cerevisiae. FEMS Yeast Res 8(3):414-24
Dultz E, et al. (2016) Global reorganization of budding yeast chromosome conformation in different physiological conditions. J Cell Biol 212(3):321-34
Tabancay AP Jr and Forsburg SL (2006) Eukaryotic DNA replication in a chromatin context. Curr Top Dev Biol 76():129-84
Lamb TM and Mitchell AP (2001) Coupling of Saccharomyces cerevisiae early meiotic gene expression to DNA replication depends upon RPD3 and SIN3. Genetics 157(2):545-56
Carrozza MJ, et al. (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6
Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19
Fazzio TG, et al. (2001) Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression. Mol Cell Biol 21(19):6450-60
Aparicio JG, et al. (2004) The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae. Mol Cell Biol 24(11):4769-80
Elkhaimi M, et al. (2000) Combinatorial regulation of phospholipid biosynthetic gene expression by the UME6, SIN3 and RPD3 genes. Nucleic Acids Res 28(16):3160-7
Bowdish KS, et al. (1994) Analysis of RIM11, a yeast protein kinase that phosphorylates the meiotic activator IME1. Mol Cell Biol 14(12):7909-19
Ratnakumar S, et al. (2011) Phenomic and transcriptomic analyses reveal that autophagy plays a major role in desiccation tolerance in Saccharomyces cerevisiae. Mol Biosyst 7(1):139-49