The 48 papers which experimentally study the biological roles of both TFs of the PCTFP (Upc2-Ecm22)
Shianna KV, et al. (2001) Identification of a UPC2 homolog in Saccharomyces cerevisiae and its involvement in aerobic sterol uptake. J Bacteriol 183(3):830-4
Kitagaki H and Takagi H (2014) Mitochondrial metabolism and stress response of yeast: Applications in fermentation technologies. J Biosci Bioeng 117(4):383-393
Klug L and Daum G (2014) Yeast lipid metabolism at a glance. FEMS Yeast Res 14(3):369-388
Germann M, et al. (2005) Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. J Biol Chem 280(43):35904-13
Jungwirth H and Kuchler K (2006) Yeast ABC transporters-- a tale of sex, stress, drugs and aging. FEBS Lett 580(4):1131-8
Yu H and Gerstein M (2006) Genomic analysis of the hierarchical structure of regulatory networks. Proc Natl Acad Sci U S A 103(40):14724-31
Zhang J, et al. (2010) Systems biology of energy homeostasis in yeast. Curr Opin Microbiol 13(3):382-8
Bussereau F, et al. (2006) The Kluyveromyces lactis repertoire of transcriptional regulators. FEMS Yeast Res 6(3):325-35
Chua G, et al. (2006) Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A 103(32):12045-50
Davies BS, et al. (2005) Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms. Mol Cell Biol 25(16):7375-85
MacPherson S, et al. (2006) A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol Mol Biol Rev 70(3):583-604
Sturley SL (2000) Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast. Biochim Biophys Acta 1529(1-3):155-63
Silver PM, et al. (2004) Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism. Eukaryot Cell 3(6):1391-7
Klimova N, et al. (2014) Phenotypic Analysis of a Family of Transcriptional Regulators, the Zinc Cluster Proteins, in the Human Fungal Pathogen Candida glabrata. G3 (Bethesda) ()
Gordan R, et al. (2011) Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol 12(12):R125
Sopko R, et al. (2006) Mapping pathways and phenotypes by systematic gene overexpression. Mol Cell 21(3):319-30
Marie C, et al. (2008) Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae. Fungal Genet Biol 45(10):1430-8
Valachovic M, et al. (2004) A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism. Lipids 39(8):747-52
Beskow A and Wright AP (2006) Comparative analysis of regulatory transcription factors in Schizosaccharomyces pombe and budding yeasts. Yeast 23(13):929-35
Vik A and Rine J (2001) Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Mol Cell Biol 21(19):6395-405
Titz B, et al. (2006) Transcriptional activators in yeast. Nucleic Acids Res 34(3):955-67
Zavrel M, et al. (2013) Comparison of Sterol Import under Aerobic and Anaerobic Conditions in Three Fungal Species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae. Eukaryot Cell 12(5):725-38
Longen S, et al. (2009) Systematic analysis of the twin cx(9)c protein family. J Mol Biol 393(2):356-68
Young ET, et al. (2000) Trinucleotide repeats are clustered in regulatory genes in Saccharomyces cerevisiae. Genetics 154(3):1053-68
Akache B and Turcotte B (2002) New regulators of drug sensitivity in the family of yeast zinc cluster proteins. J Biol Chem 277(24):21254-60
Zheng J, et al. (2010) Epistatic relationships reveal the functional organization of yeast transcription factors. Mol Syst Biol 6():420
Maguire SL, et al. (2014) Zinc Finger Transcription Factors Displaced SREBP Proteins as the Major Sterol Regulators during Saccharomycotina Evolution. PLoS Genet 10(1):e1004076
Davies BS and Rine J (2006) A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae. Genetics 174(1):191-201
Gallo-Ebert C, et al. (2013) The Yeast Anaerobic Response Element AR1b Regulates Aerobic Antifungal Drug-dependent Sterol Gene Expression. J Biol Chem 288(49):35466-77
Yang H, et al. (2015) Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2. Nat Commun 6():6129
Espenshade PJ and Hughes AL (2007) Regulation of sterol synthesis in eukaryotes. Annu Rev Genet 41:401-27
Castro R, et al. (2010) Regulatory factors controlling transcription of Saccharomyces cerevisiae IXR1 by oxygen levels: a model of transcriptional adaptation from aerobiosis to hypoxia implicating ROX1 and IXR1 cross-regulation. Biochem J 425(1):235-43
Gonzalez Siso MI and Cerdan ME (2012) Kluyveromyces lactis: A Suitable Yeast Model to Study Cellular Defense Mechanisms against Hypoxia-Induced Oxidative Stress. Oxid Med Cell Longev 2012():634674
Castro-Prego R, et al. (2010) Ixr1p regulates oxygen-dependent HEM13 transcription. FEMS Yeast Res 10(3):309-21
Kampranis SC and Makris AM (2012) Developing a yeast cell factory for the production of terpenoids. Comput Struct Biotechnol J 3():e201210006
Rintala E, et al. (2009) Low oxygen levels as a trigger for enhancement of respiratory metabolism in Saccharomyces cerevisiae. BMC Genomics 10():461
Valachovic M, et al. (2006) Cumulative mutations affecting sterol biosynthesis in the yeast Saccharomyces cerevisiae result in synthetic lethality that is suppressed by alterations in sphingolipid profiles. Genetics 173(4):1893-908
Akache B, et al. (2001) Phenotypic analysis of genes encoding yeast zinc cluster proteins. Nucleic Acids Res 29(10):2181-90
Todd RB and Andrianopoulos A (1997) Evolution of a fungal regulatory gene family: the Zn(II)2Cys6 binuclear cluster DNA binding motif. Fungal Genet Biol 21(3):388-405
Gabaldon T, et al. (2013) Comparative genomics of emerging pathogens in the Candida glabrata clade. BMC Genomics 14(1):623
Woods K and Hofken T (2016) The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways. Mol Microbiol 99(3):512-27
Babbitt GA (2010) Relaxed selection against accidental binding of transcription factors with conserved chromatin contexts. Gene 466(1-2):43-8
Whaley SG, et al. (2014) UPC2A Is Required for High-Level Azole Antifungal Resistance in Candida glabrata. Antimicrob Agents Chemother 58(8):4543-4554
Nielsen J (2009) Systems biology of lipid metabolism: from yeast to human. FEBS Lett 583(24):3905-13
Siso MI, et al. (2012) The yeast hypoxic responses, resources for new biotechnological opportunities. Biotechnol Lett 34(12):2161-73
Sameith K, et al. (2015) A high-resolution gene expression atlas of epistasis between gene-specific transcription factors exposes potential mechanisms for genetic interactions. BMC Biol 13(1):112
Nohturfft A and Zhang SC (2009) Coordination of lipid metabolism in membrane biogenesis. Annu Rev Cell Dev Biol 25:539-66
MacPherson S, et al. (2005) Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes. Antimicrob Agents Chemother 49(5):1745-52